Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier
Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier
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DOI：
10.2147/ijn.s35614
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发表时间：
2013-01-01
影响因子：
8
通讯作者：
Webster, Thomas J.
中科院分区：
文献类型：
--
作者：
Hoff, Dan;Sheikh, Lubna;Webster, Thomas J.
在本研究中，使用体外血脑屏障模型测定了11种不同氧化铁纳米颗粒（IONP）样品（8种液体和3种粉末）的渗透性。重要的是，结果显示，在血脑屏障处，铁磁流体制剂在统计学上比IONP粉末制剂更具渗透性，这表明目前研究的使用聚（乙烯基）醇、牛血清白蛋白、胶原蛋白、谷氨酸、石墨烯、以及它们的组合作为可以穿过血脑屏障递送药物或具有其它神经治疗功效的材料。相反，结果显示具有胶原制剂的IONP穿过血脑屏障的渗透性最小，表明其作为磁共振成像造影剂的作用，但限制了IONP穿过血脑屏障。对数据的进一步分析产生了几个值得注意的趋势，渗透率和流体zeta电位之间的相关性很小，但渗透率和流体颗粒尺寸之间的相关性较大（较小的颗粒尺寸具有较大的渗透率）。这些结果为简单修饰氧化铁纳米颗粒制剂以促进或抑制穿过血脑屏障奠定了基础，并且值得进一步研究以用于广泛的应用。
In the present study, the permeability of 11 different iron oxide nanoparticle (IONP) samples (eight fluids and three powders) was determined using an in vitro blood-brain barrier model. Importantly, the results showed that the ferrofluid formulations were statistically more permeable than the IONP powder formulations at the blood-brain barrier, suggesting a role for the presently studied in situ synthesized ferrofluid formulations using poly(vinyl) alcohol, bovine serum albumin, collagen, glutamic acid, graphene, and their combinations as materials which can cross the blood-brain barrier to deliver drugs or have other neurological therapeutic efficacy. Conversely, the results showed the least permeability across the blood-brain barrier for the IONP with collagen formulation, suggesting a role as a magnetic resonance imaging contrast agent but limiting IONP passage across the blood-brain barrier. Further analysis of the data yielded several trends of note, with little correlation between permeability and fluid zeta potential, but a larger correlation between permeability and fluid particle size (with the smaller particle sizes having larger permeability). Such results lay the foundation for simple modification of iron oxide nanoparticle formulations to either promote or inhibit passage across the blood-brain barrier, and deserve further investigation for a wide range of applications.