Trisomy 21 in neoplastic cells.
Trisomy 21 in neoplastic cells.
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肿瘤细胞中的 21 三体。
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
N. Mandahl
中科院分区：
文献类型：
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作者：
F. Mitelman;S. Heim;N. Mandahl
在细胞遗传学文献中已知的10，625例具有染色体畸变的人类肿瘤中，有642例描述了作为获得性克隆染色体改变的21三体。642例中共有590例（92%）为血液系统疾病和恶性淋巴瘤。21三体的发生率在急性髓性白血病（AML）、慢性髓性白血病、骨髓增生性疾病、骨髓增生异常综合征、慢性淋巴组织增生性疾病和恶性淋巴瘤中相似（4.1%-6.7%）;在急性淋巴细胞白血病（ALL）中显著较高（14.8%）。在大多数情况下，额外的21号染色体与其他数量和/或结构变化一起存在。获得性21三体是唯一的核型异常，仅占0.4%。21三体从未被报道为实体瘤中唯一的异常。细胞遗传学文献包含62例体质性21三体和恶性疾病的信息，其中肿瘤细胞已通过显带技术进行了分析。62例患者中有34例患有AML，16例患有ALL，2例患有急性未分化白血病。52例白血病唐氏综合征（DS）病例占急性白血病总数的1.4%，这一比例过高，与DS中白血病发展的风险普遍增加平行。63%的ALL患者和79%的AML患者在体质性21三体综合征上有额外的变化。这些包括几种典型的原发性白血病相关畸变：AML中的5 q-、7 q-、+8和t（8;21），以及ALL中的t（1;19）、t（4;11）、6 q-和14 q+。因此，看来，获得性核型变化的模式是相似的患者与DS和个人与正常的宪法核型。
Trisomy 21 as an acquired clonal chromosome change has been described in 642 of the 10,625 human neoplasms with chromosome aberrations known from the cytogenetic literature. A total of 590 of the 642 cases (92%) are hematologic disorders and malignant lymphomas. The incidence of trisomy 21 is similar (4.1%-6.7%) in acute myeloid leukemia (AML), chronic myeloid leukemia, myeloproliferative disorders, myelodysplastic syndromes, chronic lymphoproliferative disorders, and malignant lymphomas; it is substantially higher (14.8%) in acute lymphocytic leukemia (ALL). In most cases, the extra chromosome 21 is present together with other numerical and/or structural changes. Acquired trisomy 21 is the only karyotypic abnormality in only 0.4%. Trisomy 21 has never been reported as the sole anomaly in a solid tumor. The cytogenetic literature contains information on 62 patients with constitutional trisomy 21 and a malignant disorder in which the tumor cells have been analyzed by banding techniques. Thirty-four of the 62 patients had AML, 16 had ALL, and 2 had acute undifferentiated leukemia. The 52 leukemic Down syndrome (DS) cases account for 1.4% of the total acute leukemias, an overrepresentation that parallels the generally increased risk of leukemia development in DS. Sixty-three percent of the ALL patients and 79% of those with AML had additional changes superimposed on constitutional trisomy 21. These included several of the characteristic primary leukemia-associated aberrations: 5q-, 7q-, +8, and t(8;21) in AML, and t(1;19), t(4;11), 6q-, and 14q + in ALL. Thus, it seems that the pattern of acquired karyotypic changes is similar in patients with DS and in individuals with a normal constitutional karyotype.
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唐氏综合症急性白血病的染色体线索。
影响因子：
--
作者：
Hecht,F;Hecht,BK;Morgan,R;Sandberg,AA;Link,MP
通讯作者：
Link,MP
患有唐氏综合症的白血病：短暂性先天性骨髓增殖综合症后急性粒单核细胞白血病中 1 号和 19 号染色体之间的易位。
影响因子：
20.3
作者：
Morgan,R;Hecht,F;Cleary,ML;Sklar,J;Link,MP
通讯作者：
Link,MP
急性非淋巴细胞白血病儿童染色体异常与患者特征、组织学亚型和诱导成功的相关性。
DOI：
10.1200/jco.1985.3.1.3
发表时间：
1985
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Woods,WG;Nesbit,ME;Buckley,J;Lampkin,BC;McCreadie,S;Kim,TH;Piomelli,S;Kersey,JH;Feig,S;Bernstein,I
通讯作者：
Bernstein,I
婴儿白血病细胞染色体特征分析。
影响因子：
20.3
作者：
Pui,CH;Raimondi,SC;Murphy,SB;Ribeiro,RC;Kalwinsky,DK;Dahl,GV;Crist,WM;Williams,DL
通讯作者：
Williams,DL