Microtubule-organizing centres in binucleate cells and homosynkaryons.
Microtubule-organizing centres in binucleate cells and homosynkaryons.
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双核细胞和同型核中的微管组织中心。
DOI：
10.1242/jcs.44.1.123
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发表时间：
1980
影响因子：
4
通讯作者：
H. Harris
中科院分区：
文献类型：
--
作者：
F. Watt;E. Sidebottom;H. Harris
免疫荧光研究表明，大多数双核Vero细胞形成的病毒诱导的融合或抑制胞质分裂有一个单一的微管组织中心（MTOC）时，在重新组装的微管冷却后，但两个或两个以上的组织中心时，暴露于秋水仙胺后进行检查。这些发现表明，虽然双核细胞最初含有更多的MTOC比单核细胞，额外的MTOC通常是聚集的，所以在双核细胞中的MTOC的数量往往会很快减少到单核细胞中。
Immunofluorescence studies showed that most binucleate Vero cells formed by virus-induced fusion or by inhibition of cytokinesis had a single microtubule-organizing centre (MTOC) when examined during the reassembly of microtubules after chilling, but two or more organizing centres when examined after exposure to colcemid. These findings suggest that although binucleate cells initially contain more MTOC than mononucleate cells, the extra MTOC are normally aggregated, so that the number of MTOC in binucleate cells tends to be reduced very quickly to that in mononucleate cells.