New lobane and cembrane diterpenes from two comorian soft corals.
New lobane and cembrane diterpenes from two comorian soft corals.
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DOI：
10.3390/md8020359
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发表时间：
2010-02-23
期刊：
影响因子：
5.4
通讯作者：
Aknin M
中科院分区：
文献类型：
--
作者：
Bonnard I;Jhaumeer-Laulloo SB;Bontemps N;Banaigs B;Aknin M
对科摩罗一批软珊瑚进行了初步生物学调查，根据它们对卤虫幼虫的毒性和对乙酰胆碱酯酶的抑制作用，分别选择了两个标本，一个是肉珊瑚，另一个是叶珊瑚。生物测定引导的分级分离提供了已知的抗肿瘤促进剂西松膜二萜类化合物，（+）-肉芝醇-A（1），沿着新的洛巴烷二萜类化合物，甲氧镰孢酚（2），来自肉芝属，和一个新的西松烷类化合物crystallium E（3）.化合物1-3的结构经波谱分析和与文献值比较确定.西松烷3被发现对乙酰胆碱酯酶表现出中度抑制作用。
Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1–3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.