Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment
Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2005.09.017
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发表时间：
2006-11-01
影响因子：
4.2
通讯作者：
Alexander, G. E.
中科院分区：
文献类型：
--
作者：
Johnson, S. C.;Schmitz, T. W.;Alexander, G. E.
这项研究检查了轻度认知障碍遗忘型（MCI）患者内侧颞叶（MTL）和后扣带（PC）的功能，MCI是一种使患者患阿尔茨海默病（AD）风险更高的综合征。功能磁共振成像（fMRI）用于识别77名健康中青年在编码新项目和识别以前学习过的项目时的正常活动区域。该组的激活模式指导了14名轻度认知障碍受试者和14名年龄匹配的对照组之间的进一步比较。MCI患者在识别先前学习过的项目时，PC和编码新项目时右海马体的活动较少，尽管任务表现与对照组相当。MTL中fMRI信号变化的减少支持了先前有关海马编码新信息的研究。PC信号变化的减少与最近的研究结果一致，这些研究表明PC在正常成年人的识别中所起的作用，以及在有AD遗传或认知风险的人群中代谢下降的作用。我们的研究结果表明，PC功能的改变可能部分解释了AD患者记忆回忆失败的原因。(c) 2005爱思唯尔公司版权所有。
This study examined the functionality of the medial temporal lobe (MTL) and posterior cingulate (PC) in mild cognitive impairment amnestic type (MCI), a syndrome that puts patients at greater risk for developing Alzheimer disease (AD). Functional MRI (fMRI) was used to identify regions normally active during encoding of novel items and recognition of previously learned items in a reference group of 77 healthy young and middle-aged adults. The pattern of activation in this group guided further comparisons between 14 MCI subjects and 14 age-matched controls. The MCI patients exhibited less activity in the PC during recognition of previously learned items, and in the right hippocampus during encoding of novel items, despite comparable task performance to the controls. Reduced fMRI signal change in the MTL supports prior studies implicating the hippocampus for encoding new information. Reduced signal change in the PC converges with recent research on its role in recognition in normal adults as well as metabolic decline in people with genetic or cognitive risk for AD. Our results suggest that a change in function in the PC may account, in part, for memory recollection failure in AD. (c) 2005 Elsevier Inc. All rights reserved.