Serum Galectin-3 Levels Predict Recurrences after Ablation of Atrial Fibrillation.
Serum Galectin-3 Levels Predict Recurrences after Ablation of Atrial Fibrillation.
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DOI：
10.1038/srep34357
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发表时间：
2016-09-28
影响因子：
4.6
通讯作者：
Babuty D
中科院分区：
文献类型：
--
作者：
Clementy N;Benhenda N;Piver E;Pierre B;Bernard A;Fauchier L;Pages JC;Babuty D
半乳糖凝集素-3（Galectin-3）是纤维化和心房重构的生物标志物，参与心房颤动（AF）的发生和维持机制。我们试图研究半乳糖凝集素-3水平预测消融术后房颤复发的准确性。在我们中心进行AF消融的连续系列患者中测定半乳糖凝集素-3的血清浓度。在3个月的空白期后，在所有患者中收集第一年内复发的房性心律失常，在3个月、6个月和12个月时使用霍尔特监测。共纳入160例患者，平均半乳糖凝集素-3率为14.4 ± 5.6 ng/mL。12个月时，55例患者（34%）再次发生持续性房性心律失常。只有较高的半乳糖凝集素-3水平（HR = 1.07 [1.01-1.12]，p = 0.02）和较大的左心房直径（HR = 1.07 [1.03-1.12]，p = 0.001）独立预测复发。半乳糖凝集素-3水平<15 ng/mL且左心房直径<40 mm的患者在单次手术后无房颤生存率为91%，而半乳糖凝集素-3水平≥ 15且左心房直径≥40的患者为41%（p < 0.0001），无论房颤是阵发性还是持续性。Galectin-3和左心房直径，而不是房颤的临床表现，预测消融后复发。
Galectin-3 is a biomarker of fibrosis and atrial remodeling, involved in the mechanisms of initiation and maintenance of atrial fibrillation (AF). We sought to study the accuracy of galectin-3 level in predicting recurrences of AF after ablation. Serum concentrations of galectin-3 were determined in a consecutive series of patients addressed for AF ablation in our center. After a 3-month blanking period, recurrences of atrial arrhythmias were collected during the first year in all patients, using Holter monitoring at 3, 6 months and 12 months. A total of 160 patients were included, with a mean galectin-3 rate was 14.4 ± 5.6 ng/mL. At 12-month, 55 patients (34%) had reexperienced sustained atrial arrhythmia. Only higher galectin-3 level (HR = 1.07 [1.01–1.12], p = 0.02) and larger left atrial diameter (HR = 1.07 [1.03–1.12], p = 0.001) independently predicted recurrence. Patients with both galectin-3 level <15 ng/mL and left atrial diameter <40 millimeters had a 1-year arrhythmia-free survival rate − after a single procedure without anti-arrhythmic drug − of 91%, as compared with 41% in patients with galectin-3 ≥ 15 and left trial diameter ≥40 (p < 0.0001), whether AF was paroxysmal or persistent. Galectin-3 and left atrial diameters, rather than clinical presentation of AF, predict recurrences after ablation.
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影响因子：
5
作者：
Gruson, D.;Mancini, M.;Rousseau, M. F.
通讯作者：
Rousseau, M. F.
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影响因子：
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作者：
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通讯作者：
Xu, Yawei
影响因子：
24
作者：
Mohanty, Sanghamitra;Mohanty, Prasant;Natale, Andrea
通讯作者：
Natale, Andrea
影响因子：
3.7
作者：
Kornej J;Schmidl J;Ueberham L;John S;Daneschnejad S;Dinov B;Hindricks G;Adams V;Husser D;Bollmann A
通讯作者：
Bollmann A
DOI：
10.1016/j.ijcme.2014.10.003
发表时间：
2014-11-01
期刊：
IJC METABOLIC & ENDOCRINE
影响因子：
--
作者：
Clementy, Nicolas;Piver, Eric;Babuty, Dominique
通讯作者：
Babuty, Dominique