Tetrandrine Inhibits Wnt/β-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer
Tetrandrine Inhibits Wnt/β-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer
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DOI：
10.1124/mol.110.068668
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发表时间：
2011-02-01
影响因子：
3.6
通讯作者：
He, Tong-Chuan
中科院分区：
文献类型：
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作者：
He, Bai-Cheng;Gao, Jian-Li;He, Tong-Chuan
作为最常见的恶性肿瘤之一，结肠癌是由Wnt/ β -连环蛋白通路异常激活引发的。尽管一些患者的治疗选择有所增加，但总体进展并不明显。因此，迫切需要开发新的治疗方法。我们发现双苄基异喹啉生物碱粉防己碱（TET）具有抗癌活性。TET是一种钙通道阻滞剂，用于治疗高血压和心律失常。在这里，我们研究TET抗癌活性的分子基础。我们将TET与8种癌症的6种化疗药物进行比较，发现TET具有与喜树碱、长春新碱、紫杉醇和阿霉素相当的抗癌活性，并且优于5-氟尿嘧啶（5-FU）和卡铂。TET IC50是
As one of the most common malignancies, colon cancer is initiated by abnormal activation of the Wnt/beta-catenin pathway. Although the treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. We have found that bisbenzylisoquinoline alkaloid tetrandrine (TET) exhibits anticancer activity. TET is used as a calcium channel blocker to treat hypertensive and arrhythmic conditions in Chinese medicine. Here, we investigate the molecular basis underlying TET's anticancer activity. We compare TET with six chemotherapy drugs in eight cancer lines and find that TET exhibits comparable anticancer activities with camptothecin, vincristine, paclitaxel, and doxorubicin, and better than that of 5-fluorouracil (5-FU) and carboplatin. TET IC50 is