The impact of cerebrovascular aging on vascular cognitive impairment and dementia.
The impact of cerebrovascular aging on vascular cognitive impairment and dementia.
复制标题
脑血管衰老对血管性认知障碍和痴呆的影响
DOI：
10.1016/j.arr.2016.09.007
复制
发表时间：
2017-03
影响因子：
13.1
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Yang T;Sun Y;Lu Z;Leak RK;Zhang F
随着人类预期寿命的延长，老年人口将会增加。衰老伴随着组织结构的变化，通常会导致功能衰退。例如，血管内的衰老导致流向重要器官的血流量减少，可能导致器官萎缩和功能丧失。在中枢神经系统中，脑血管老化会导致血脑屏障的完整性丧失，最终导致认知和感觉运动能力下降。血管性认知损害和痴呆(VCID)是慢性脑低灌注所致认知功能障碍的主要类型之一。尽管最近VCID的临床和实验研究取得了进展，但我们对血管在VCID发病机制中的作用的了解仍然非常有限。在这篇综述中，我们总结了关于VCID的最新发现，重点是血管年龄相关的病理及其在这种疾病发展中的作用。
As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. In the central nervous system, cerebral vascular aging can lead to loss of the integrity of the blood-brain barrier, eventually resulting in cognitive and sensorimotor decline. One of the major of types of cognitive dysfunction due to chronic cerebral hypoperfusion is vascular cognitive impairment and dementia (VCID). In spite of recent progress in clinical and experimental VCID research, our understanding of vascular contributions to the pathogenesis of VCID is still very limited. In this review, we summarize recent findings on VCID, with a focus on vascular age-related pathologies and their contribution to the development of this condition.