Silicon ATR crystal with subwavelength structures optimized for blood analysis
Silicon ATR crystal with subwavelength structures optimized for blood analysis
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具有亚波长结构的硅 ATR 晶体，针对血液分析进行了优化
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Gloria Zörnack
中科院分区：
文献类型：
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作者：
Lorenz Sykora;A. Müller;A. Kondratiev;A. Roth;Vitalii Mozin;Axel Fehr;Gloria Zörnack
利用红外光谱进行血液分析具有很高的潜力。为了将红外光谱应用于临床，需要一种具有成本效益的采样方法，高样品通量，小样品尺寸（< 15μl）和低检测限。研制了一种新型的亚波长采样面ATR晶体。结构和分析物形成有效的介质层，其支持相消干涉。吸收信号可以增强至少一个数量级。微结构还充当代替血液离心的微筛。可以通过改变微结构的尺寸来针对感兴趣的波长区域优化增强。第一步解决这个高维反设计问题的不同的神经网络架构。
Using infrared spectroscopy for blood analysis has a high potential. In order to bring infrared spectroscopy to clinics, a cost-effective sampling approach, high sample throughput, small sample sizes (< 15μl) and a low detection limit are required. A novel ATR crystal with subwavelength structures on the sampling side was developed and fabricated. The structures and the analyte form an effective medium layer, which supports destructive interference. The absorption signal can be enhanced by at least one order of magnitude. The microstructures also act as a micro sieve that replaces blood centrifugation. The enhancement can be optimized for wavelength regions of interest by changing the dimensions of the microstructures. First steps towards the solution of this high dimensional inverse design problem were made with different neural network architectures.