Can the acoustic change complex be recorded in an individual with a cochlear implant? Separating neural responses from cochlear implant artifact
Can the acoustic change complex be recorded in an individual with a cochlear implant? Separating neural responses from cochlear implant artifact
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DOI：
10.3766/jaaa.18.2.5
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发表时间：
2007-02-01
影响因子：
1.2
通讯作者：
Martin, Brett A.
中科院分区：
文献类型：
--
作者：
Martin, Brett A.
本病例研究的目的是确定P1-N1-P2声学变化复合波（ACC）是否可以在人工耳蜗植入个体中记录。在耳蜗植入接受者中，来自植入物的刺激相关伪影可能与感兴趣的诱发电位重叠，使得难以确定记录的反应是神经反应还是伪影的简单反映。这对于ACC是更大的技术挑战，因为使用具有相对长持续时间的刺激。该受试者是一名24岁的患者，诊断为听神经病/听觉不同步，并在其左耳使用了MED-EL克里思+人工耳蜗植入体。ACC被记录到在中点处包含F2变化的合成元音，范围从0（无变化）到1200 Hz（感知为/ui/）。通过扬声器以75 dB SPL随机呈现刺激。在一种情况下，受试者忽略刺激并观看字幕视频。在另一个实验中，如果受试者在刺激中点感知到声学变化，则按下响应板上的一个按钮，如果没有，则按下另一个按钮。用32个头皮电极记录皮层听觉诱发电位。结果表明，ACC是存在的，可以戏弄除了人工耳蜗刺激伪影。ACC阈值表现出良好的协议与行为的歧视性能，因此，结果是积极的潜在的临床应用的ACC技术与人工耳蜗植入体的个人。
The purpose of this case study was to determine whether the P1-N1-P2 acoustic change complex (ACC) could be recorded in an individual with a cochlear implant. In a cochlear implant recipient, stimulus-related artifact from the implant can overlap the evoked potential of interest, making it difficult to determine whether the recorded response is neural or a simple reflection of the artifact. This is an even greater technical challenge for the ACC because stimuli having relatively long durations are used. The subject was a 24-year-old with a diagnosis of auditory neuropathy/auditory dys-synchrony and used a MED-EL Tempo+ cochlear implant in her left ear. The ACC was recorded to synthetic vowels containing a change of F2 at midpoint ranging from 0 (no change) to 1200 Hz (perceived as /ui/). The stimuli were presented randomly at 75 dB SPL via a loudspeaker. In one condition the subject ignored the stimuli and watched a captioned video. In the other, the subject pressed one button on a response pad if she perceived an acoustic change at stimulus midpoint and another if she did not. Cortical auditory evoked potentials were recorded from 32 scalp electrodes. Results indicated that the ACC was present and could be teased apart from the cochlear implant stimulus artifact. ACC thresholds showed good agreement with behavioral discrimination performance, and therefore, results are positive for the potential clinical application of the ACC technique to individuals with cochlear implants.