Delayed activation and retrograde propagation in cardiac muscle: implication of virtual electrode effects.
Delayed activation and retrograde propagation in cardiac muscle: implication of virtual electrode effects.
复制标题
心肌的延迟激活和逆行传播：虚拟电极效应的影响。
DOI：
10.1114/1.1326029
复制
发表时间：
2000
影响因子：
3.8
通讯作者：
WikswoJr,JP
中科院分区：
文献类型：
--
作者：
Wu,J;Roden,DM;WikswoJr,JP
心脏组织的点阴极刺激先前被示出产生狗骨形的虚拟阴极横向于肌纤维和两个纵向虚拟阳极。我们假设，虚拟阳极可以导致一个区域的延迟激活，分离两个区域的早期激活所造成的虚拟阴极。使用高密度电极阵列在42个灌流心外膜切片从14只犬左心室，我们观察到的早期和延迟激活和不同的途径逆行传播对应的早期模式的区域。从横向定位的早期激活区通过延迟激活区向阴极，以及从早期激活区直接向阴极，可以看到逆行传播。这些通路在逆行传播方向上的离散度很大（相对于阈激动快轴为2° ± 31°，n= 179;径向速度：0.5 ± 0.2m/s，n= 95，取自8个心脏的12个切片，刺激330 μs，0.8-30 mA）。在10个心脏的13个切片中记录的23个标测图（不同刺激强度）中，观察到与轴成0° ± 6°（n= 32）的延迟激活。我们的结论是，点阴极刺激诱导延迟激活沿着纤维轴和逆行传播沿着和横向的轴。©2000 Biomedical Engineering Society.PAC00：8719Ff，8719Hh，8716Uv，8754Dt，8719Nn
Point cathodal stimulation of cardiac tissue was shown previously to produce both a dog-bone shaped virtual cathode transverse to the muscle fibers and two longitudinal virtual anodes. We hypothesize that virtual anodes can cause a region of delayed activation, separating two regions of early activation caused by the virtual cathode. Using a high-density electrode array in 42 superfused epicardial slices from 14 canine left ventricles, we observed regions of early and delayed activation and different pathways of retrograde propagation corresponding to the earlier patterns. Retrograde propagation was seen from the transversely located early activation area through areas of delayed activation toward the cathode, and from the early activation area toward the cathode directly. These pathways caused a wide dispersion in the direction of retrograde propagation (2° ± 31°,n= 179, relative to the fast axis of threshold activation; radial velocity: 0.5 ± 0.2m/s,n= 95, in 12 slices from 8 hearts with stimuli of 330 μs, 0.8–30 mA). Delayed activations were observed 0° ± 6° (n= 32) from the axis in 23 maps (at differing stimulation strengths) recorded in 13 slices from 10 hearts. We conclude that point cathodal stimulation induce delayed activation along the fiber axis and retrograde propagation both along and transverse to the axis. ©2000 Biomedical Engineering Society.PAC00: 8719Ff, 8719Hh, 8716Uv, 8754Dt, 8719Nn