Comparison of redox parameters in ovarian endometrioma and its malignant transformation
Comparison of redox parameters in ovarian endometrioma and its malignant transformation
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DOI：
10.3892/ol.2018.9242
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发表时间：
2018-10-01
期刊：
影响因子：
2.9
通讯作者：
Kobayashi, Hiroshi
中科院分区：
文献类型：
--
作者：
Fujimoto, Yoshikatsu;Imanaka, Shogo;Kobayashi, Hiroshi
本研究旨在通过测量与疾病进展相关的8-羟基-2-脱氧鸟苷（8-OHdG）、血红素加氧酶-1（HO-1）和总抗氧化能力（TAC/血红素铁）的变化，评估良性卵巢上皮瘤（OE）及其恶变[卵巢上皮癌相关性卵巢癌（EAOC）]中氧化应激和抗氧化标志物的水平。采用酶联免疫吸附试验对44例OE和14例EAOC患者的囊液样本进行了研究。使用SPSS 22.0版进行A（2）检验、t检验和Pearson相关性检验。应用受试者工作特征曲线分析评价各指标诊断EAOC的临界点、敏感性和特异性。EAOC组囊液8-OHdG和HO-1水平较OE组显著降低（P=0.013和P
The present study aimed to evaluate the levels of oxidative stress and antioxidant markers in benign endometrioma (OE) and its malignant transformation [endometriosis-associated ovarian cancer (EAOC)] by measuring 8-hydroxy-2-deoxyguanosine (8-OHdG), heme oxygenase-1 (HO-1) and total antioxidant capacity (TAC/Heme-iron) alterations associated with disease progression. Cyst fluid samples from 44 patients with OE and 14 patients with EAOC were studied using an enzyme-linked immunosorbent assay. A (2) test, t-test and Pearson correlation test were performed using SPSS version 22.0. The cut-off point, sensitivity and specificity of each marker for EAOC diagnosis were evaluated by receiver operating characteristic curve analysis. Cyst fluid 8-OHdG and HO-1 levels in the EAOC group were significantly decreased compared with the OE subjects (P=0.013 and P