The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
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DOI：
10.1016/s0092-8674(00)81827-9
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发表时间：
1996-12-27
期刊：
影响因子：
64.5
通讯作者：
Tonegawa, S
中科院分区：
文献类型：
--
作者：
Tsien, JZ;Huerta, PT;Tonegawa, S
我们使用一种新的通用方法，允许CA1限制性基因敲除，产生了一种NMDAR1基因的缺失仅限于海马区CA1锥体细胞的小鼠品系。这些突变的小鼠成年后没有明显的异常。成年小鼠缺乏NMDA受体介导的突触电流和CA1突触的长时程增强，表现出空间记忆受损，但非空间学习没有受损。我们的结果有力地表明，由NMDA受体介导的CA1突触的活性依赖性修饰在空间记忆的获得中发挥着重要作用。
We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.