Relationship between blood pressure level and mortality rate: an 18‐year study conducted in two rural communities in Japan
Relationship between blood pressure level and mortality rate: an 18‐year study conducted in two rural communities in Japan
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血压水平与死亡率之间的关系：在日本两个农村社区进行的一项为期 18 年的研究
DOI：
10.1097/00004872-200018020-00002
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发表时间：
2000
影响因子：
4.9
通讯作者：
K. Shimamoto
中科院分区：
文献类型：
--
作者：
S. Takagi;S. Saitoh;Masahiro Nakano;Yoshito Hayashi;F. Obara;Hirofumi Onishi;K. Shimamoto
背景在日本，根据血压分层对心血管疾病的生命预后进行的研究很少。因此，在日本，虽然高血压的治疗是可能的，尽管有时很困难，但由于各种抗高血压药物的可用性，开始治疗的适当时间仍然是一个问题。目的根据日本人群的血压分层，探讨日本普通人群心血管疾病的长期预后。设计一项以社区为基础的前瞻性队列研究，对1996名年龄在40岁至64岁之间的男性和女性进行了为期18年的基线检查。从当地公共卫生护士和死亡证明处获得死亡信息。通过向死者住院的医院的医生发送调查问卷来澄清死亡原因，并在基线检查时对每个血压类别的死亡原因进行分析。结果在日本普通人群中，心血管疾病的死亡率随血压水平的升高而升高，在校正了年龄、性别和其他心血管危险因素后，收缩压≥ 140 mmHg组和舒张压≥ 90 mmHg组的死亡率显著较高。然而，心血管疾病的死亡风险与收缩压和舒张压没有J形关系。结论我们得出结论，日本人开始治疗的最佳时间是血压为140/90 mmHg或更低。
Background There have been very few studies on life prognosis of cardiovascular disease according to blood pressure stratifiation in the Japanese. Therefore, in Japan, although treatment of hypertension is possible, albeit at times difficult, due to the availability of various antihypertensive medications, the appropriate time at which treatment should be started remains a problem. Objective To investigate the long-term prognosis of cardiovascular disease in the Japanese general population according to blood pressure stratification in the Japanese. Design A community-based prospective cohort study of 1996 men and women between the ages of 40 and 64 years at the baseline examination was conducted over an 18-year period. Information on death was obtained from local public health nurses and death certificates. The causes of death were clarified by questionnaires sent to doctors in the hospital in which the deceased was hospitalized, and the causes of death were analysed in each blood pressure category at baseline examination. Results Mortality from cardiovascular disease increased with increases in the level of blood pressure and was significantly higher in ≥ 140 mmHg group in systolic blood pressure and ≥ 90 mmHg group in diastolic blood pressure, adjusted for age, sex and other cardiovascular risk factors in the Japanese general population. However, mortality risk from cardiovascular disease did not have a J-shaped relationship with systolic and diastolic blood pressure. Conclusion We conclude that the optimum time for starting treatment in Japanese people is when blood pressure is 140/90 mmHg or less.