VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells
VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells
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DOI：
10.1016/j.bbrc.2007.06.094
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发表时间：
2007-08-31
影响因子：
3.1
通讯作者：
Iwama, Toru
中科院分区：
文献类型：
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作者：
Oka, Naoki;Soeda, Akio;Iwama, Toru
越来越多的证据表明恶性脑肿瘤中存在癌症干细胞（CSC），这些CSC可能在肿瘤的发生、生长和复发中起关键作用。血管内皮生长因子（VEGF）促进血管内皮细胞（VECs）的增殖和神经干细胞的神经发生。使用来自人胶质母细胞瘤的CSC和表达VEGF的逆转录病毒，我们研究了VEGF对体外和体内CSC性质的影响。尽管VEGF在体外并不影响CSC的性质，但用表达VEGF的CSC注射小鼠脑导致富含血管的GBM大量扩张、肿瘤相关出血和高发病率，这表明VEGF通过血管生成促进肿瘤发生。这些结果表明，VEGF诱导血管内皮细胞增殖的血管丰富的肿瘤环境中，所谓的干细胞龛。(c)2007爱思唯尔公司All rights reserved.
There is increasing evidence for the presence of cancer stem cells (CSCs) in malignant brain tumors, and these CSCs may play a pivotal role in tumor initiation, growth, and recurrence. Vascular endothelial growth factor (VEGF) promotes the proliferation of vascular endothelial cells (VECs) and the neurogenesis of neural stem cells. Using CSCs derived from human glioblastomas and a retrovirus expressing VEGF, we examined the effects of VEGF on the properties of CSCs in vitro and in vivo. Although VEGF did not affect the property of CSCs in vitro, the injection of mouse brains with VEGF-expressing CSCs led to the massive expansion of vascular-rich GBM, tumor-associated hemorrhage, and high morbidity, suggesting that VEGF promoted tumorigenesis via angiogenesis. These results revealed that VEGF induced the proliferation of VEC in the vascular-rich tumor environment, the so-called stem cell niche. (c) 2007 Elsevier Inc. All rights reserved.