EFFECT OF SUGAR ALCOHOLS ON THE COMPOSITION AND METABOLISM OF A MIXED CULTURE OF ORAL BACTERIA GROWN IN A CHEMOSTAT
EFFECT OF SUGAR ALCOHOLS ON THE COMPOSITION AND METABOLISM OF A MIXED CULTURE OF ORAL BACTERIA GROWN IN A CHEMOSTAT
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DOI：
10.1159/000261977
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发表时间：
1994-07-01
期刊：
影响因子：
4.2
通讯作者：
MARSH, PD
中科院分区：
文献类型：
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作者：
BRADSHAW, DJ;MARSH, PD
木糖醇和山梨糖醇是有效的非致龋糖替代品。许多研究表明，木糖醇可能具有额外的减少龋齿的作用。本研究探讨了木糖醇和山梨糖醇，当脉冲与葡萄糖一起，口腔细菌生长在恒化器的混合培养物的组成和代谢的影响。在该系统中，木糖醇具有降低葡萄糖脉冲时酸产生的速率和程度的效果，与单独脉冲的葡萄糖相比，使酸敏感物种能够以更大的数量持续存在。此外，木糖醇阻止了在没有pH控制的情况下葡萄糖脉冲后观察到的变形链球菌的富集。相反，山梨醇具有相反的作用，S。变形杆菌比例增加。该研究为木糖醇影响牙菌斑生态从而降低龋齿率的机制提供了证据。
Xylitol and sorbitol are effective as non-cariogenic sugar substitutes. A number of studies suggest that xylitol may have an additional, caries-reducing effect. This study examines the effect of xylitol and sorbitol, when pulsed together with glucose, on the composition and metabolism of a mixed culture of oral bacteria grown in a chemostat. In this system, xylitol had the effect of reducing the rate and extent of acid production when pulsed with glucose, compared with glucose pulsed alone, enabling acid-sensitive species to persist in greater numbers. Furthermore, the enrichment of Streptococcus mutans, observed following glucose pulses in the absence of pH control, was prevented by xylitol. In contrast, sorbitol had the opposite effects and S. mutans increased in proportion. The study provides evidence for a mechanism by which xylitol could affect the ecology of dental plaque and thereby reduce the rate of dental caries.