Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk.
Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk.
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DOI：
10.18632/oncotarget.19233
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发表时间：
2017-08-29
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Fan Y;Jin X;Man C;Gao Z;Wang X
饮食的炎症潜力与结直肠癌（CRC）风险之间的联系并不一致。该荟萃分析旨在评估饮食炎症指数（DII）评分估计的饮食炎症潜力与CRC风险的相关性。检索了PubMed和Embase数据库中从开始到2017年2月的相关研究。选择所有研究DII评分与CRC风险相关性的队列和病例对照研究。包括四个前瞻性队列和四个病例对照研究，共招募了880，380名参与者。最高DII评分与最低分类的CRC合并调整风险比（RR）为1.43（95%置信区间[CI]：1.26-1.62）。当按研究设计分层时，病例对照和队列研究的RR分别为1.27（95% CI：1.16-1.38）和1.81（95% CI：1.48-2.22）。亚组分析显示，DII评分最高的个体与男性CRC风险独立相关（RR=1.51; 95% CI：1.29-1.76），女性（RR=1.25; 95%CI：1.10-1.41）、结肠癌（RR=1.39; 95%CI：1.19-1.62）和直肠癌（RR=1.32; 95%CI：1.01-1.74）。然而，在前瞻性队列研究中，直肠癌的汇总RR为1.07（95%CI：0.87-1.31）。通过高DII评分估计，促炎饮食与CRC风险增加独立相关。这一发现证实了低炎症可能性饮食可以降低CRC风险。然而，性别和癌症部位特异性DII评分与CRC风险的相关性需要进一步研究。
The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case–control studies investigating the association of the DII score with CRC risk were selected. Four prospective cohorts and four case–control studies, which enrolled a total of 880,380 participants, were included. The pooled adjusted risk ratio (RR) of CRC for the highest DII score versus the lowest category was 1.43 (95% confidence interval [CI]: 1.26–1.62). When stratified by study design, the RRs for the case–control and cohort studies were 1.27 (95% CI: 1.16–1.38) and 1.81 (95% CI: 1.48–2.22), respectively. Subgroup analysis showed that individuals with the highest category of DII score were independently associated with CRC risk in men (RR=1.51; 95% CI: 1.29–1.76), women (RR=1.25; 95% CI: 1.10–1.41), colon cancer (RR=1.39; 95% CI: 1.19–1.62), and rectal cancer (RR=1.32; 95% CI: 1.01–1.74). However, the pooled RR was 1.07 (95% CI: 0.87–1.31) for rectal cancer among the prospective cohort studies. As estimated by a high DII score, pro-inflammatory diet is independently associated with increased CRC risk. This finding confirms that low inflammatory potential diet may reduce CRC risk. However, the gender- and cancer site-specific associations of the DII score with CRC risk need to be further investigated.
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影响因子：
2.3
作者：
Tabung, Fred K.;Steck, Susan E.;Ma, Yunsheng;Liese, Angela D.;Zhang, Jiajia;Caan, Bette;Hou, Lifang;Johnson, Karen C.;Mossavar-Rahmani, Yasmin;Shivappa, Nitin;Wactawski-Wende, Jean;Ockene, Judith K.;Hebert, James R.
通讯作者：
Hebert, James R.
影响因子：
3.6
作者：
Shivappa, Nitin;Zucchetto, Antonella;Hebert, James R.
通讯作者：
Hebert, James R.
DOI：
10.1007/s00432-014-1711-6
发表时间：
2014-09-01
影响因子：
3.6
作者：
Galas, Aleksander;Kulig, Jan
通讯作者：
Kulig, Jan
影响因子：
2.4
作者：
Hardman WE
通讯作者：
Hardman WE
影响因子：
3.2
作者：
Folsom, Aaron R.;Parker, Emily D.;Harnack, Lisa J.
通讯作者：
Harnack, Lisa J.