Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens
Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens
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DOI：
10.1128/jvi.03220-14
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发表时间：
2016-01-01
影响因子：
5.4
通讯作者：
Cristea, Ileana M.
中科院分区：
文献类型：
--
作者：
Budayeva, Hanna G.;Rowland, Elizabeth A.;Cristea, Ileana M.
多年来，沉默调节蛋白酶被认为是细胞环境的有效“传感器”，可以快速将信息传递到不同的细胞途径。人们花了很多精力来探索它们在人类癌症和衰老中的作用。然而，越来越多的文献使这些酶成为病毒学领域的焦点。在这里，我们讨论了沉默调节蛋白的功能，在病毒感染的背景下，它提供了针对病原体的治疗干预的监管点。
For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.