Genital human papillomavirus infection in Panama City prostitutes.
Genital human papillomavirus infection in Panama City prostitutes.
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巴拿马城妓女生殖器人乳头瘤病毒感染。
DOI：
10.1093/infdis/160.4.599
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Rawls,WE
中科院分区：
文献类型：
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作者：
Reeves,WC;Arosemena,JR;Garcia,M;deLao,SL;Cuevas,M;Quiroz,E;Caussy,D;Rawls,WE
对于高危人群女性生殖器人乳头瘤病毒 (HPV) 感染的自然史知之甚少。从 183 名巴拿马城妓女身上采集了样本，并进行了 HPV（过滤原位 DNA 杂交）和性传播媒介的评估。对队列进行了 8 个月的随访； 51% 的受试者每月完成四次回访，16% 的受试者接受八次采样。随着连续检测样本数量的增加，发现感染 HPV 的女性比例显着增加； 183 名女性中，有 38 名 (21%) 在一次就诊后呈阳性，而 56 名女性在完成六次就诊后，有 46 名 (82%) 被感染。随着时间的推移，病毒检测的模式不是随机的，这意味着大多数妓女持续感染生殖器 HPV，并且出现分散的感染灶或潜伏病毒的周期性重新激活。我们的研究结果表明，为了准确估计 HPV 感染率并确定是否存在 DNA 表达模式，需要进行多次采样。
Little is known of the natural history of genital human papillomavirus (HPV) infections in women from high-risk populations. Samples were collected from 183 Panama City prostitutes and assessed for HPV (filter in situ DNA hybridization) and for sexually transmitted agents. The cohort was followed for 8 mo; 51% of subjects completed four monthly return visits and 16% were sampled eight times. The proportion of women found infected with HPV increased significantly with increasing numbers of consecutive samples tested; 38 (21%) of 183 women were positive after one visit and 46 (82%) of 56 who completed six visits were infected. The pattern of viral detection over time was not random, which implied that most prostitutes were persistently infected with genital HPVs and that either scattered foci of infection or periodic reactivation of latent virus occurred. Our findings suggest that multiple sampling is necessary to accurately estimate HPV infection rates and to define whether patterns of DNA expression are present.