Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind.
Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind.
复制标题
盲人区域自发脑活动和灰质体积的变化。
DOI：
10.1155/2015/141950
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发表时间：
2015
影响因子：
3.1
通讯作者：
Yu C
中科院分区：
文献类型：
--
作者：
Jiang A;Tian J;Li R;Liu Y;Jiang T;Qin W;Yu C
视觉剥夺可引起局部自发脑活动（RSBA）的改变。然而，致盲年龄对RSBA的影响以及RSBA的改变与盲人脑结构之间的关系尚不清楚。在这项研究中，我们进行了休息状态的功能和结构磁共振成像50视力控制和91盲人（20先天性失明，27早期失明，44晚盲个人）。与正常对照组相比，我们发现盲人在初级和高级视觉区的RSBA增加，而在归因于感觉运动和显着网络的大脑区域的RSBA减少。相反，盲人受试者在视觉区表现出显着减少的灰质体积（GMV），而他们表现出显着增加的GMV在感觉运动区。失明年龄与视区GMV呈负相关，而对RSBA的影响较为复杂。最后，RSBA和GMV值之间呈显著负相关。我们的研究结果表明，视觉剥夺后RSBA和GMV的系统依赖性，反向改变。此外，失明的发病年龄对RSBA和GMV的重组有不同的影响。
Visual deprivation can induce alterations of regional spontaneous brain activity (RSBA). However, the effects of onset age of blindness on the RSBA and the association between the alterations of RSBA and brain structure are still unclear in the blind. In this study, we performed resting-state functional and structural magnetic resonance imaging on 50 sighted controls and 91 blind subjects (20 congenitally blind, 27 early blind, and 44 late blind individuals). Compared with the sighted control, we identified increased RSBA in the blind in primary and high-level visual areas and decreased RSBA in brain regions which are ascribed to sensorimotor and salience networks. In contrast, blind subjects exhibited significantly decreased gray matter volume (GMV) in the visual areas, while they exhibited significantly increased GMV in the sensorimotor areas. Moreover, the onset age of blindness was negatively correlated with the GMV of visual areas in blind subjects, whereas it exerted complex influences on the RSBA. Finally, significant negative correlations were shown between RSBA and GMV values. Our results demonstrated system-dependent, inverse alterations in RSBA and GMV after visual deprivation. Furthermore, the onset age of blindness has different effects on the reorganizations in RSBA and GMV.