Body size and composition and the risk of lymphohematopoietic malignancies
Body size and composition and the risk of lymphohematopoietic malignancies
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DOI：
10.1093/jnci/dji209
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发表时间：
2005-08-03
影响因子：
10.3
通讯作者：
Giles, GG
中科院分区：
文献类型：
--
作者：
MacInnis, RJ;English, DR;Giles, GG
关于身体大小和成分与淋巴造血系统恶性肿瘤风险之间的关系的报道一直不一致。在一项对40909名年龄在27-75岁的人进行的前瞻性研究中，我们平均随访8.4年，测量了脂肪质量和脱脂质量(使用生物电阻抗分析)，并直接测量了腰围。所有的恶性肿瘤都是通过人口癌症登记来确定的。与体重指数(25 kg/m(2)相比)、超重和肥胖者的危险比[HR]=5.3，95%可信区间[CI]=1.9~15.2和HR=5.0，95%CI分别为1.6~15.5和P=0.006；腰围(每10厘米增加HR=1.35，95%CI=1.06至1.72；P=0.02)。淋巴增生性恶性肿瘤及其亚型与体型关系不大。
Reports of associations between body size and composition and risk of lymphohematopoietic malignancies have been inconsistent. In a prospective study of 40909 people aged 27-75 years and followed up for an average of 8.4 years, we measured fat mass and fat-free mass (using bioelectrical impedance analysis) and measured waist circumference directly. All malignancies were ascertained via the population cancer registry. The risk of myeloid leukemia was positively associated with body mass index (compared with those 25 kg/m(2), overweight and obese persons' hazard ratios [HRs] = 5.3, 95% confidence interval [CI] = 1.9 to 15.2 and HR = 5.0, 95% CI 1.6 to 15.5, respectively; P = .006), fat-free mass (per 10-kg increase HR = 1.83, 95% CI = 1.15 to 2.90; P = .01), and waist circumference (per 10-cm increase HR = 1.35, 95% CI = 1.06 to 1.72; P = .02). Lymphoproliferative malignancies and subgroups showed little relationship with body size.