CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
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DOI：
10.4049/jimmunol.180.10.6947
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发表时间：
2008-05-15
影响因子：
4.4
通讯作者：
Matthay, Michael A.
中科院分区：
文献类型：
--
作者：
Su, Xiao;Johansen, Mette;Matthay, Michael A.
CD47 调节中性粒细胞向感染或损伤部位的迁移。缺乏 CD47 的小鼠容易感染大肠杆菌 (E. coli) 腹膜炎。然而，人们对 CD47 在急性肺部炎症和损伤发展中的作用知之甚少。在这项研究中，我们发现缺乏 CD47 的小鼠可以免受 LPS 诱导的急性肺损伤和大肠杆菌肺炎的影响，并显着减少肺水肿、肺血管通透性和菌血症。用CD47(-/-)中性粒细胞重建CD47(+/-)小鼠可显着减少肺水肿和中性粒细胞浸润，从而证明CD47(+)中性粒细胞是大肠杆菌肺炎肺损伤发展所必需的。重要的是，患有大肠杆菌肺炎的 CD47 缺陷小鼠的存活率有所提高。总而言之，CD47 缺乏可以保护小鼠免受 LPS 诱导的急性肺损伤和大肠杆菌肺炎的影响。靶向CD47可能是治疗急性肺损伤的新途径。
CD47 modulates neutrophil transmigration toward the sites of infection or injury. Mice lacking CD47 are susceptible to Escherichia coli (E. coli) peritonitis. However, less is known concerning the role of CD47 in the development of acute lung inflammation and injury. In this study, we show that mice lacking CD47 are protected from LPS-induced acute lung injury and E. coli pneumonia with a significant reduction in pulmonary edema, lung vascular permeability, and bacteremia. Reconstitution of CD47(+/-) mice with CD47(-/-) neutrophils significantly reduced lung edema and neutrophil infiltration, thus demonstrating that CD47(+) neutrophils are required for the development of lung injury from E. coli pneumonia. Importantly, CD47-deficient mice with E. coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury.