Acid-degradable polymers for drug delivery: a decade of innovation
Acid-degradable polymers for drug delivery: a decade of innovation
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DOI：
10.1039/c2cc36589h
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Stenzel, Martina H.
中科院分区：
文献类型：
--
作者：
Binauld, Sandra;Stenzel, Martina H.
在酸性条件下开始降解的聚合物越来越多地被研究为一旦药物载体到达微酸性肿瘤环境或在药物载体已被细胞吸收后触发药物释放的途径，导致聚合物定位在酸性内体和溶酶体中。本文综述了近年来酸降解聚合物及其药物释放系统的研究进展。各种酸不稳定基团，如缩醛、原酸酯、腙、亚胺和顺乌头基，其可以在微酸性条件下经历裂解，已经用于产生聚合物结构或聚合物-药物缀合物，其可以在溶酶体和内体条件下降解，触发药物或DNA的快速释放。
Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic endosomes and lysosomes. The advances in the design of acid-degradable polymers and drug delivery systems have been summarized and discussed in this review article. Various acid-labile groups such as acetals, orthoester, hydrazones, imines and cis-aconityl, that can undergo cleavage in slightly acidic conditions, have been employed to create polymer architectures or polymer-drug conjugates that can degrade under lysosomal and endosomal conditions, triggering the fast release of drugs or DNA.