An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium.
An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium.
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一种急性肺部综合征，可能代表涉及肺间质的急性移植物抗宿主病。
DOI：
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发表时间：
1991
影响因子：
4.8
通讯作者：
A. Concannon
中科院分区：
文献类型：
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作者：
Kerry Atkinson;J. Turner;J. Biggs;Anthony J. Dodds;A. Concannon
1例因血液系统恶性肿瘤接受异基因骨髓移植的患者发生急性肺综合征，可能代表急性移植物抗宿主病（GVHD），涉及肺结核。他在第34天出现皮肤和肠道急性GVHD，这与咳嗽、呼吸困难和胸部X线不对称变化有关。肺活检显示间质和支气管周围淋巴细胞浸润和急性支气管上皮变性。他对大剂量静脉注射甲泼尼龙有反应。放射性变化完全消退。这个病例被认为是涉及肺结核的GVHD，强调了在骨髓移植后非细菌性肺病的管理中需要组织采购。
An acute pulmonary syndrome possibly representing acute graft-versus-host disease (GVHD) involving lung interstitium occurred in a patient given an allogeneic bone marrow transplant for haematological malignancy. He presented at day 34 with acute GVHD of skin and bowel, and this was associated with cough, dyspnoea and an asymmetrical change on chest X-ray. Lung biopsy demonstrated an interstitial and peribronchial lymphocytic infiltrate and acute bronchial epithelial degeneration. He responded symptomatically to high dose intravenous methylprednisolone. The radiological change resolved completely. This case, thought to represent GVHD involving lung interstitium, emphasizes the need for tissue procurement in the management of non-bacterial lung disease after marrow transplantation.