Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21WAF1/CIP1 and proliferating cell nuclear antigen
Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21WAF1/CIP1 and proliferating cell nuclear antigen
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DOI：
10.1016/j.canlet.2009.05.001
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发表时间：
2009-11-18
期刊：
影响因子：
9.7
通讯作者：
Mori, Masatomo
中科院分区：
文献类型：
--
作者：
Masuo, Takashige;Okamura, Shinichi;Mori, Masatomo
本研究探讨了钙调神经磷酸酶（CaN）在人结直肠癌增殖中的作用。CaN活性和蛋白表达在人结直肠癌中增加。核转录因子NFAT是CaN的生理底物，在人结肠癌标本和人结肠癌细胞系中被激活。CaN抑制剂环孢素A（CsA）减少这些细胞系中的细胞生长。CsA可降低c-Myc和增殖细胞核抗原（PCNA）的表达，但可增加p21（WAF 1/CIP 1）的表达。提示CaN可能通过调节c-Myc、p21（WAF 1/CIP 1）和PCNA的表达水平促进大肠癌细胞增殖。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
The present study investigated the role of Calcineurin (CaN) in the proliferation of human colorectal cancers. CaN activity and protein expression were increased in human colorectal cancers. Nuclear transcription factor NFAT, a physiological substrate for CaN, was activated in human colon cancer specimen as well as in the human colon cancer cell lines. CaN inhibitor cyclosporine A (CsA) reduced cell growth in these cell lines. CsA decreased the expressions of c-Myc and the proliferating cell nuclear antigen (PCNA) but also increased p21(WAF1/CIP1) expression. Our results suggest that CaN promotes colorectal cancer proliferation probably by regulating levels of c-Myc, p21(WAF1/CIP1) and PCNA. (C) 2009 Elsevier Ireland Ltd. All rights reserved.