CeIIML: its future, present and past
CeIIML: its future, present and past
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DOI：
10.1016/j.pbiomolbio.2004.01.004
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发表时间：
2004-06-01
影响因子：
3.8
通讯作者：
Nielsen, PF
中科院分区：
文献类型：
--
作者：
Lloyd, CM;Halstead, MDB;Nielsen, PF
生物技术和实验技术的进步导致阐明了大量的生物学数据。数学模型提供了一种分析此数据的方法。但是，有两个问题需要解决：（1）需要定义单元模型的标准，因此可以在全球范围内交换它们，并以一致的格式读取仿真软件，并且2）消除当前模型发布方法出现的错误。 CellML已经发展为满足建模社区的这些需求。 CELIML是一种基于定义细胞功能数学模型的基于自由的，开源，可扩展的标记语言标准。在本文中，我们总结了CellML的结构，其当前的应用（包括生物途径和电生理模型），以及其未来在未来的开发，工具集的开发以及本体论的整合。 （c）2004 Elsevier Ltd.保留所有权利。
Advances in biotechnology and experimental techniques have lead to the elucidation of vast amounts of biological data. Mathematical models provide a method of analysing this data; however, there are two issues that need to be addressed: (1) the need for standards for defining cell models so they can, for example, be exchanged across the World Wide Web, and also read into simulation software in a consistent format and (2) eliminating the errors which arise with the current method of model publication. CellML has evolved to meet these needs of the modelling community. CelIML is a free, open-source, eXtensible markup language based standard for defining mathematical models of cellular function. In this paper we summarise the structure of CellML, its current applications (including biological pathway and electrophysiological models), and its future development-in particular, the development of toolsets and the integration of ontologies. (C) 2004 Elsevier Ltd. All rights reserved.