Effect of cytotoxic T-lymphocyte antigen-4, TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis.
Effect of cytotoxic T-lymphocyte antigen-4, TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis.
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DOI：
10.3978/j.issn.1000-9604.2013.11.06
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发表时间：
2013-12
期刊：
影响因子：
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通讯作者：
Jianwei Liu;Junli Wang;Weiping Jiang;Yujin Tang
中科院分区：
文献类型：
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作者：
Jianwei Liu;Junli Wang;Weiping Jiang;Yujin Tang
目的 既往研究探讨了细胞毒性T淋巴细胞抗原4（CTLA-4）和肿瘤坏死因子-α（TNF-α）在骨肉瘤癌变中的作用，但结果不一致。我们旨在通过荟萃分析阐明 CTLA-4、TNF-α 多态性与骨肉瘤风险之间的关联。方法 我们在 PubMed、EMbase、Cochrane 图书馆、Google Scholar 数据库、中国知网 (CNKI) 和 2013 年 3 月之前发表的人类会议文献中不受语言限制地检索相关研究。通过比值比 (OR) 和 95% 置信区间 (95% CI) 估计遗传变异与骨肉瘤风险之间的关联强度。结果 总共选择了 7 项研究，涉及 1,198 名骨肉瘤患者和 1,493 名对照者。四项研究符合 CTLA-4 条件（1,003 例骨肉瘤和 1,162 例对照），三项研究符合 TNF-α 条件（195 例骨肉瘤和 331 例对照）。汇总结果显示，CTLA-4 rs231775 多态性与骨肉瘤风险相关（GG 与 AA：OR=1.63，95% CI=1.24-2.13；GG + GA 与 AA：OR=1.56，95% CI=1.21-2.01；AA + GA 与 GG：OR=0.83，95% CI=0.71-0.97；G 与 A：OR=1.21，95% CI=1.08-1.36）。各项研究中未观察到显着的异质性。 CTLA-4 的 rs5742909 多态性或 TNF-α 的 rs1800629 多态性与骨肉瘤风险之间没有发现显着关联。结论这些结果表明CTLA-4的rs231775多态性可能在骨肉瘤的癌变过程中发挥重要作用。
OBJECTIVE Previous studies have investigated the role of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and tumor necrosis factor-alpha (TNF-α) in carcinogenesis of osteosarcoma, but their results were inconsistent. We aimed to clarify the associations between CTLA-4, TNF-α polymorphism and osteosarcoma risk by using meta-analysis. METHODS We searched relevant studies without language restriction in PubMed, EMbase, Cochrane Library, Google Scholar databases, Chinese National Knowledge Infrastructure (CNKI) and conference literature in humans published prior to March 2013. The strengths of the associations between genetic variants and osteosarcoma risk were estimated by odds ratio (OR) with 95% confidence interval (95% CI). RESULTS A total of seven studies with 1,198 osteosarcoma patients and 1,493 controls were selected. Four studies were eligible for CTLA-4 (1,003 osteosarcoma and 1,162 controls), and three studies for TNF-α (195 osteosarcoma and 331 controls). Pooled results showed that rs231775 polymorphism of CTLA-4 was associated with osteosarcoma risk (GG vs. AA: OR=1.63, 95% CI=1.24-2.13; GG + GA vs. AA: OR=1.56, 95% CI=1.21-2.01; AA + GA vs. GG: OR=0.83, 95% CI=0.71-0.97; G vs. A: OR=1.21, 95% CI=1.08-1.36). No significant heterogeneity was observed across the studies. No significant associations were found between rs5742909 polymorphism of CTLA-4 or rs1800629 polymorphism of TNF-α and osteosarcoma risk. CONCLUSIONS These results suggest that the rs231775 polymorphism of CTLA-4 may play an important role in carcinogenesis of osteosarcoma.