Difference in the expression of inflammatory mediators in gingival crevicular fluid in postmenopausal patients with chronic periodontitis with and without menopausal hormone therapy
Difference in the expression of inflammatory mediators in gingival crevicular fluid in postmenopausal patients with chronic periodontitis with and without menopausal hormone therapy
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DOI：
10.1016/j.eurox.2019.100021
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发表时间：
2019-07-01
影响因子：
2.6
通讯作者：
Bascones-Martinez, Antonio
中科院分区：
文献类型：
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作者：
Arias-Herrera, Santiago;Bascones-Ilundian, Cristina;Bascones-Martinez, Antonio
目的：女性激素变化会对牙周组织产生显著影响。本研究的目的是评估绝经期激素治疗在诊断为中度慢性牙周炎和绝经期患者的临床和免疫学结果方面是否有有益的效果。研究设计：选择30名患有中度慢性牙周炎和更年期的受试者，根据是否接受更年期激素治疗分为两组。对两组患者牙周临床参数、微生物学样本和免疫学指标进行评估。使用非配对学生t检验和卡方检验评估组间差异。采用Pearson系数相关法确定变量之间的相关性。结果：两组患者临床附着水平、探查袋深度、白细胞介素1 β、白细胞介素6差异均有统计学意义。非绝经期激素治疗服用者吸烟习惯、PPD加深、Il-6水平升高，易导致白细胞介素1ss GCF水平升高。这些发现得到了血清雌激素水平的支持。绝经期激素治疗组的变量水平更高。结论：在本研究的限制范围内，绝经期激素治疗的妇女在牙周状况和免疫变量方面比未绝经期激素治疗的妇女有更好的差异的假设得到支持。(c) 2019年作者。这是一篇基于CC by-nc-nd许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）的开放获取文章。
Objective: Hormonal changes experience by women produce significant changes in the periodontium. The aim of this study is to assess whether menopausal hormone therapy, in patients diagnosed with moderate chronic periodontitis and menopause presents a beneficial effect, in terms of clinical and immunological outcomes. Study design: Thirty subjects with moderate chronic periodontitis and menopause were selected and assigned to two groups in accordance to the presence of menopausal hormone therapy. Periodontal clinical parameters, microbiological samples and immunological variables were assessed in both groups. Inter-group differences were evaluated using non-paired Student t-tests and chi square tests. Also, Pearson coefficient correlation was performed to determine the correlation between variables. Results: There were statistically significant differences between groups for clinical attachment level, probing pocket depth, interleukin 1 beta and interleukin 6. Smoking habit, deeper PPD and higher Il-6 levels in non-menopausal hormone therapy users group, tend to increase the interleukin 1ss GCF levels. These findings were supported by serum estrogen levels. The variables levels were higher in the menopausal hormone therapy users group. Conclusion: Within the limitations of the present study, the hypothesis that menopausal hormone therapy user's women will show better periodontal status and differences in immunological variables respect to those being non-menopausal hormone therapy users was supported. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).