Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK
Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK
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DOI：
10.1097/qad.0b013e32833cbb5b
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发表时间：
2010-09-24
期刊：
影响因子：
3.8
通讯作者：
Fidler, Sarah
中科院分区：
文献类型：
--
作者：
Fox, Julie;Castro, Hannah;Fidler, Sarah
目的：描述英国男男性行为者 (MSM) 中非 B HIV-1 亚型的频率和危险因素。设计：观察性研究。方法：对 1980 年至 2007 年期间诊断为 HIV-1 感染的 MSM 进行鉴定，并确定英国 HIV 耐药数据库中保存的 HIV 基因型。收集蛋白酶和逆转录酶序列并使用 REGA 算法确定病毒进化枝。使用逻辑回归分析人口变量和亚型之间的关联。结果：英国 MSM 中非 B HIV-1 感染的患病率为 5.4% (437/8058)。在英国，从 1996 年之前到 2002 年，这一比例随着诊断年份的增加而增加，随后在 2002 年之后保持相对稳定在 7-9% 左右，最近在 2007 年增加到 13%。多变量分析显示，非 B 族 HIV-1 感染的获得与 HIV 诊断晚年 (P < 0.001)、黑人种族 (P < 0.001) 和非欧洲出生国家 (P = 0.01) 独立相关。年龄还与亚型相关，25-39 岁的个体感染非 B 病毒的可能性低于 25 岁以下的个体（P = 0.01）。将分析限制在英国出生的白人男性，亚型与诊断年份之间的关联仍然具有统计学意义（P < 0.001），与年龄的关联也是如此（P < 0.001）。讨论：英国感染非 B 分支 HIV-1 的 MSM 数量正在增加，表明全球 HIV-1 病毒亚型之间的社会人口学界限正在缩小。如果病毒亚型与临床疾病进展或疫苗设计相关，则需要考虑不断变化的分布模式。 (C) 2010 年 Wolters Kluwer Health 垂直条 Lippincott Williams & Wilkins
Objectives: To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK.Design: Observational study.Methods: MSM diagnosed with HIV-1 infection from 1980-2007, with HIV genotype held in the UK HIV Drug Resistance Database were identified. Protease and reverse transcriptase sequences were collected and viral clade determined using the REGA algorithm. Associations between demographic variables and subtype were analysed using logistic regression.Results: The prevalence of non-B HIV-1 infection amongst MSM in the UK was 5.4% (437/8058). In the UK this increased with year of diagnosis from pre1996 to 2002, and has subsequently remained relatively stable at around 7-9% after 2002, with a recent increase in 2007 to 13%. Multivariate analysis showed that acquisition of non-B HIV-1 infection was independently associated with later year of HIV diagnosis (P < 0.001), black ethnicity (P < 0.001) and non-European country of birth (P = 0.01). Age was also associated with subtype with individuals aged 25-39 years being less likely to have non-B virus than those aged less than 25 years (P = 0.01). Restricting the analysis to white men born in the UK, the association between subtype and year of diagnosis remained statistically significant (P < 0.001), as did the association with age (P < 0.001).Discussion: The number of MSM in the UK infected with non-B clade HIV-1 is increasing, suggesting that the sociodemographic boundaries between HIV-1 viral subtypes globally are diminishing. Should viral subtypes be relevant to clinical disease progression or vaccine design, the changing pattern of distribution will need to be taken into account. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins