LOCALIZATION AND QUANTITATION OF A LOW-MOLECULAR WEIGHT PROTEINASE-INHIBITOR, ANTI-LEUKOPROTEASE, IN THE HUMAN-UTERUS
LOCALIZATION AND QUANTITATION OF A LOW-MOLECULAR WEIGHT PROTEINASE-INHIBITOR, ANTI-LEUKOPROTEASE, IN THE HUMAN-UTERUS
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DOI：
10.1515/bchm2.1981.362.2.953
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
OHLSSON, K
中科院分区：
文献类型：
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作者：
CASSLEN, B;ROSENGREN, M;OHLSSON, K
在宫颈粘膜中发现了抗白细胞蛋白酶，但在子宫内膜中不存在。免疫组织学显示其在宫颈隐窝的上皮衬里中占主导地位。宫颈粘液中发现高浓度。尽管子宫内膜中不存在抗白细胞蛋白酶，但在子宫液中发现了低浓度，可能继发于宫颈粘液的扩散。宫颈粘液中抗白细胞蛋白酶的浓度在月经周期期间变化很大，但没有发现周期中期最低值。大多数女性在月经开始前一周采集的样本中发现浓度增加。抗白细胞蛋白酶以游离形式存在于未使用宫内节育器 (IUD) 的子宫液中。对于液体形式的宫内节育器使用者来说，它部分是自由形式，部分是复杂形式。非复合部分的主要部分具有生物活性。该复合物至少部分由与抗白细胞蛋白酶结合的弹性蛋白酶组成。因此，抗白细胞蛋白酶可能有助于中和宫内节育器使用者子宫液中的粒细胞弹性蛋白酶。
Antileukoprotease was demonstrated in the cervical mucosa, but was absent in the endometrium. It was shown immunohistologically to predominate in the epithelial lining of the cervical crypts. High concentrations were found in the cervical mucus. Although antileukoprotease was not present in the endometrium, low concentrations were found in the uterine fluid, probably secondary to diffusion from the cervical mucus. The concentration of antileukoprotease in cervical mucus varied greatly during the menstrual cycle, but no midcycle minimum was found. Increased concentrations were found in samples obtained during the week preceding onset of menstruation in most women. Antileukoprotease was present in uterine fluid from intrauterine device (IUD) non-users in its free form. In fluid form IUD users it was partly in its free form, and partly in a complexed form. The major part of the non-complexed portion was biologically active. The complex consisted, at least partly, of elastase bound to antileukoprotease. Antileukoprotease may thus contribute to the neutralization of granulocyte elastase in the uterine fluid of IUD users.