Disturbed functional connectivity within the left prefrontal cortex and sensorimotor areas predicts impaired cognitive speed in patients with first-episode schizophrenia
Disturbed functional connectivity within the left prefrontal cortex and sensorimotor areas predicts impaired cognitive speed in patients with first-episode schizophrenia
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DOI：
10.1016/j.pscychresns.2018.03.001
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发表时间：
2018-05-30
影响因子：
2.3
通讯作者：
Harciarek, Michal
中科院分区：
文献类型：
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作者：
Krukow, Pawel;Jonak, Kamil;Harciarek, Michal
本研究旨在确定异常的皮质-皮质功能连接模式，可以预测精神分裂症患者的认知减慢。一组32例首发精神分裂症患者和可比的健康对照进行静息态qEEG和认知评估。采用相位滞后指数（PLI）作为连接性指数，并在六个频率下分析同步。成对的电极被分组以分别覆盖额、颞、中央、顶叶和枕区。PLI计算了区域内连接和区域间连接。计算机版本的处理速度测试，以控制可能的认知效率在执行任务的波动。在患者组中，与健康对照组相比，θ频率记录的PLI值显著较高，尤其是在后部区域，而额叶区域内低α频率的PLI值降低。患者组中伽马频率的平均PLI也较低。回归分析表明，较低的区域内PLI左额叶皮层和较高的PLI在theta带的体感皮层，以及未经治疗的精神病的持续时间，被证明是显着的预测功能受损的处理速度在首发患者。我们的研究证实，皮质-皮质同步中断有助于精神分裂症的认知减慢。
This study aimed at identifying abnormal cortico-cortical functional connectivity patterns that could predict cognitive slowing in patients with schizophrenia. A group of thirty-two patients with the first-episode schizophrenia and comparable healthy controls underwent resting-state qEEG and cognitive assessment. Phase Lag Index (PLI) was applied as a connectivity index and the synchronizations were analyzed in six frequencies. Pairs of electrodes were grouped to separately cover frontal, temporal, central, parietal and occipital regions. PLI was calculated for intra-regional connectivity and between-regions connectivity. Computer version processing speed tests were applied to control for possible fluctuations in cognitive efficiency during the performance of the tasks. In the group of patients, in comparison to healthy controls, significantly higher PLI values were recorded in theta frequency, especially in the posterior areas and decreased PLI in low-alpha frequency within the frontal regions. Mean PLI in gamma frequency was also lower in the patients group. Regression analysis showed that lower intra-regional PLI for left frontal cortex and higher PLI within somatosensory cortex in theta band, together with the duration of untreated psychosis, proved to be significant predictors of impaired processing speed in first-episode patients. Our investigation confirmed that disrupted cortico-cortical synchronization contributes to cognitive slowing in schizophrenia.