INCREASED ADVENTITIAL MAST-CELLS IN A PATIENT WITH CORONARY SPASM
INCREASED ADVENTITIAL MAST-CELLS IN A PATIENT WITH CORONARY SPASM
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DOI：
10.1056/nejm198510313131807
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
VIRMANI, R
中科院分区：
文献类型：
--
作者：
FORMAN, MB;OATES, JA;VIRMANI, R
尽管冠状动脉痉挛是许多缺血性心脏综合征的重要组成部分，但其病因仍不明确。许多假设已被考虑来解释产生局灶性血管高反应性的机制。我们对自主神经系统的研究，以及血栓素a2代谢物的测量和强效环加氧酶抑制剂的治疗都不能支持血栓素在冠状动脉痉挛发病机制中的作用。78910因此，我们研究了血管壁的细胞浸润可能是血管收缩因子的来源的可能性，11并且现在检查了冠状动脉血管，该患者具有典型的冠状动脉痉挛和…
ALTHOUGH coronary spasm is an important component of a number of ischemic cardiac syndromes,123456its cause or causes remain ill-defined. Numerous hypotheses have been considered to explain the mechanisms producing focal vascular hyperreactivity. Our investigations of the autonomic nervous system, and both measurement of thromboxane A2metabolites and treatment with potent cyclooxygenase inhibitors failed to support the role of thromboxanes in the pathogenesis of coronary spasm.78910Accordingly, we studied the possibility that cellular infiltration of the vessel wall could be a source of vasoconstrictor factors,11and have now examined coronary vessels in a patient with well-characterized coronary spasm and . . .