Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.
Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.
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DOI：
10.1016/j.neuroscience.2018.07.051
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发表时间：
2018-09-15
期刊：
影响因子：
3.3
通讯作者：
Dobrunz LE
中科院分区：
文献类型：
--
作者：
Sun HY;Li Q;Bartley AF;Dobrunz LE
短期可塑性使得突触强度能够通过输入时间动态调节。来自同一轴突的兴奋性突触对抑制性神经元和兴奋性神经元的短期可塑性可以具有深刻不同的突触前形式。我们以前表明，谢弗侧支突触到大多数海马CA1放射层中间神经元有较少的成对脉冲促进比突触到CA1锥体细胞，但在稳态短期抑郁症的差异不大。然而，很少有人知道如何突触到interneurons响应时间复杂的模式，发生在体内。在这里，我们比较了谢弗侧支突触到放射层中间神经元和锥体细胞在急性海马切片的生理来源的穗火车。我们发现，中间神经元上的突触比锥体细胞上的突触具有更少的短期易化，并且一个子集仅表达短期抑制。数学模型预测，这种靶细胞特异性的短期可塑性通过初始释放概率的差异而发生。所有这三个组有更多的短期促进在生理衍生的列车刺激比在恒定频率的刺激在相同的频率，这表明刺激时间的可变性是很重要的。这些目标细胞的具体差异，短期可塑性降低强度的兴奋性输入到中间神经元相对于锥体细胞，抑郁症中间神经元相对于促进中间神经元，在列车的高频部分。这在25°C和33°C下以类似的程度发生，并且在生理细胞外钙下甚至更大。靶细胞特异性的短期可塑性差异使突触具有不同的时间滤波特性，这可能有助于动态调节CA1抑制和兴奋的平衡。
Short-term plasticity enables synaptic strength to be dynamically regulated by input timing. Excitatory synapses arising from the same axon can have profoundly different presynaptic forms of short-term plasticity onto inhibitory and excitatory neurons. We previously showed that Schaffer collateral synapses onto most hippocampal CA1 stratum radiatum interneurons have less paired-pulse facilitation than synapses onto CA1 pyramidal cells, but little difference in steady-state short-term depression. However, less is known about how synapses onto interneurons respond to temporally complex patterns that occur in vivo. Here we compared Schaffer collateral synapses onto stratum radiatum interneurons and pyramidal cells in acute hippocampal slices in response to physiologically-derived spike trains. We find that synapses onto interneurons have less short-term facilitation than synapses onto pyramidal cells, and a subset expresses only short-term depression. Mathematical modeling predicts this target-cell specific short-term plasticity occurs through differences in initial release probability. All three groups have more short-term facilitation during physiologically-derived train stimulation than during constant-frequency stimulation at the same frequency, indicating that variability in stimulus timing is important. These target-cell specific differences in short-term plasticity reduce the strength of excitatory input onto interneurons relative to pyramidal cells, and of depression interneurons relative to facilitation interneurons, during high frequency portions of the train. This occurs to a similar extent at 25°C and at 33°C, and is even greater at physiological extracellular calcium. Target-cell specific differences in short-term plasticity enable synapses to have different temporal filtering characteristics, which may help to dynamically regulate the balance of inhibition and excitation in CA1.
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影响因子：
5.5
作者：
Kerr, Michael I.;Wall, Mark J.;Richardson, Magnus J. E.
通讯作者：
Richardson, Magnus J. E.
影响因子：
5.3
作者：
Eltes, Timea;Kirizs, Tekla;Holderith, Noemi
通讯作者：
Holderith, Noemi
影响因子：
2.1
作者：
Jeong, SM;Hahm, KD;Han, SM
通讯作者：
Han, SM
DOI：
10.1016/s0736-5748(02)00015-1
发表时间：
2002-06-01
影响因子：
1.8
作者：
Dobrunz, LE
通讯作者：
Dobrunz, LE
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU