Human monoclonal antibodies.
Human monoclonal antibodies.
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人单克隆抗体。
DOI：
10.1093/oxfordjournals.bmb.a071978
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发表时间：
1984
期刊：
影响因子：
64.8
通讯作者：
A. Neville
中科院分区：
文献类型：
--
作者：
K. Sikora;A. Neville
单克隆抗体（MCAs）允许精确定义复杂结构（如细胞表面和细胞骨架）中的单个分子组分。针对人抗原产生的小鼠和大鼠MCA已经鉴定了多种临床感兴趣的分子。事实上，这些抗体已经显示出在癌症诊断中具有临床用途，既通过提供肿瘤负荷的标志物，又用于肿瘤沉积物的放射定位。癌症的治疗试验已经开始使用异种抗体。
Monoclonal antibodies (MCAs) allow the precise definition of individual molecular components in complex structures such as the cell surface and the cytoskeleton. Mouse and rat MCAs raised against human antigens have identified a variety of molecules of clinical interest. Indeed such antibodies are already being shown to have clinical use in the diagnosis of cancer, both by providing markers of tumour load and for the radiolocalization of tumour deposits. Therapeutic trials in cancer have already begun using xenogeneic antibodies.