SDF1 Polymorphisms Influence Outcome in Patients with Symptomatic Cardiovascular Disease.
SDF1 Polymorphisms Influence Outcome in Patients with Symptomatic Cardiovascular Disease.
复制标题
SDF1多态性影响症状性心血管疾病患者的结果。
DOI：
10.1371/journal.pone.0161933
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Geisler T
中科院分区：
文献类型：
--
作者：
Rath D;Schaeffeler E;Winter S;Hewer J;Müller K;Droppa M;Stimpfle F;Gawaz M;Schwab M;Geisler T
SDF1 and its cognate receptors CXCR4 and CXCR7 are involved in myocardial repair and are associated with outcome in cardiovascular patients. Hence, we aimed to investigate clinically significant SDF1 SNPs for their prognostic impact in patients with cardiovascular disease. Genotyping for selected SDF1 variants (rs1065297, rs2839693, rs1801157, rs266087, rs266085 and rs266089 was performed in patients (n = 872) who underwent percutaneous coronary intervention. Carriers of variant rs2839693 and rs266089 showed significantly higher cumulative event-free survival compared with non-carriers. All other polymorphisms had no relevant influence on outcome. Multivariate Cox regression analysis showed a significant correlation of these SNPs with cardiovascular outcome after inclusion of clinical and prognostic relevant variables (hazard ratio (HR) 0.51 (95% CI 0.30–0.88), p = 0.015 and [HR 0.51 (95% CI 0.30–0.88), p = 0.016, respectively). In addition, multivariate Cox regression with SDF1 haplotypes revealed a significantly reduced risk for the haplotype carrying the minor alleles of rs2839693 and rs266089 (HR 0.47 (95% CI 0.27–0.84), p = 0.011). Distinct SDF1 polymorphisms are associated with improved cardiovascular prognosis in CAD patients. Further studies are warranted to validate these results and to better describe the endogenous regeneration potential in carriers of these SNPs. Targeted, genotype guided therapeutic approaches to foster myocardial regeneration and thus cardiovascular prognosis should be evaluated in future.
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DOI：
10.1056/nejmoa072366
发表时间：
2007-08-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Samani NJ;Erdmann J;Hall AS;Hengstenberg C;Mangino M;Mayer B;Dixon RJ;Meitinger T;Braund P;Wichmann HE;Barrett JH;König IR;Stevens SE;Szymczak S;Tregouet DA;Iles MM;Pahlke F;Pollard H;Lieb W;Cambien F;Fischer M;Ouwehand W;Blankenberg S;Balmforth AJ;Baessler A;Ball SG;Strom TM;Braenne I;Gieger C;Deloukas P;Tobin MD;Ziegler A;Thompson JR;Schunkert H;WTCCC and the Cardiogenics Consortium
通讯作者：
WTCCC and the Cardiogenics Consortium
影响因子：
37.8
作者：
Stellos, Konstantinos;Langer, Harald;Gawaz, Meinrad
通讯作者：
Gawaz, Meinrad
影响因子：
21.3
作者：
Gillette, Jennifer M.;Larochelle, Andre;Dunbar, Cynthia E.;Lippincott-Schwartz, Jennifer
通讯作者：
Lippincott-Schwartz, Jennifer
DOI：
10.1016/j.bbrc.2013.12.065
发表时间：
2014-01-17
影响因子：
3.1
作者：
Gu, Xiao-Long;Ma, Na;Ma, Lan
通讯作者：
Ma, Lan
影响因子：
10.4
作者：
Rath, D.;Chatterjee, M.;Geisler, T.
通讯作者：
Geisler, T.