Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist
Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist
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DOI：
10.1016/s0165-6147(97)01066-3
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发表时间：
1997-06-01
影响因子：
13.8
通讯作者：
Seabrook, GR
中科院分区：
文献类型：
--
作者：
Bristow, LJ;Kramer, MS;Seabrook, GR
本文综述了一种新的高亲和力和选择性多巴胺D4受体拮抗剂L-745，870的发现及其临床试验结果。尽管有几条证据表明选择性D4受体拮抗剂可能是一种有效的抗精神病药物，诱导锥体外系副作用的倾向较低，但L-745，870在人体中作为抗精神病药物无效。
The discovery of a novel high-affinity and selective dopamine D4 receptor antagonist, L-745,870, and the results of clinical trials with this compound are reviewed. Despite several lines of evidence which suggest that a selective D4 receptor antagonist may be an effective antipsychotic agent with a lower propensity to induce extrapyramidal side-effects, L-745,870 was ineffective as an antipsychotic in humans.