K(ATP) channels process nucleotide signals in muscle thermogenic response.
K(ATP) channels process nucleotide signals in muscle thermogenic response.
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DOI：
10.3109/10409238.2010.513374
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发表时间：
2010-12
影响因子：
6.5
通讯作者：
Alekseev AE
中科院分区：
文献类型：
--
作者：
Reyes S;Park S;Terzic A;Alekseev AE
肌膜ATP敏感性钾通道（KATP）是细胞内腺嘌呤核苷酸唯一的门控通道，在严重的能量损伤下起着保护细胞的作用。最近，KATP通道已被建立在非应激生理状态下连续控制肌肉能量消耗。这些进展提出了一个问题，即KATP通道如何在每个代谢系统都被设置为缓冲核苷酸库的环境中处理细胞能量学的趋势。揭示肌肉中KATP通道驱动的产热反应的机制基础，因此邀请能量和蛋白质的细胞内区室化的概念，沿着核苷酸信号传导越过扩散屏障。此外，它需要深入了解与KATP通道复合物相关的内在ATP酶活性的可逆性。尽管操作范例，肌膜KATP通道的稳态作用，现在可以扩大到更广泛的环境线索影响代谢健康。以这种方式，在能量不足的条件下，如缺血性损伤或肾上腺素能应激，KATP通道复合物的操作将导致保护性能量节省，保护肌肉性能和完整性。在能量过剩的情况下，KATP通道功能的下调可能会在与肥胖、冷耐受不良和相关代谢紊乱相关的能量失衡的条件下发现潜在的影响。
Uniquely gated by intracellular adenine nucleotides, sarcolemmal ATP-sensitive K+ (KATP) channels have been typically assigned to protective cellular responses under severe energy insults. More recently, KATP channels have been instituted in the continuous control of muscle energy expenditure under non-stressed, physiological states. These advances raised the question of how KATP channels can process trends in cellular energetics within a milieu where each metabolic system is set to buffer nucleotide pools. Unveiling the mechanistic basis of the KATP channel-driven thermogenic response in muscles thus invites the concepts of intracellular compartmentalization of energy and proteins, along with nucleotide signaling over diffusion barriers. Furthermore, it requires gaining insight into the properties of reversibility of intrinsic ATPase activity associated with KATP channel complexes. Notwithstanding the operational paradigm, the homeostatic role of sarcolemmal KATP channels can be now broadened to a wider range of environmental cues affecting metabolic well-being. In this way, under conditions of energy deficit such as ischemic insult or adrenergic stress, the operation of KATP channel complexes would result in protective energy saving, safeguarding muscle performance and integrity. Under energy surplus, downregulation of KATP channel function may find potential implications in conditions of energy imbalance linked to obesity, cold intolerance and associated metabolic disorders.
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影响因子：
4.8
作者：
Bienengraeber, M;Alekseev, AE;Terzic, A
通讯作者：
Terzic, A
影响因子：
4.4
作者：
Arrell, D. Kent;Zlatkovic, Jelena;Kane, Garvan C.;Yamada, Satsuki;Terzic, Andre
通讯作者：
Terzic, Andre
影响因子：
4.8
作者：
Abraham, MR;Selivanov, VA;Terzic, A
通讯作者：
Terzic, A
影响因子：
56.9
作者：
Baukrowitz, T;Schulte, U;Fakler, B
通讯作者：
Fakler, B
影响因子：
4.8
作者：
Crawford, RM;Ranki, HJ;Jovanovic, A
通讯作者：
Jovanovic, A