A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat
A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat
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DOI：
10.1126/science.1133649
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发表时间：
2006-11-24
期刊：
影响因子：
56.9
通讯作者：
Dubcovsky, Jorge
中科院分区：
文献类型：
--
作者：
Uauy, Cristobal;Distelfeld, Assaf;Dubcovsky, Jorge
提高粮食作物的营养价值是改善人类营养和健康的一种手段。我们报道了GPC-B1的定位克隆，这是一个与籽粒蛋白质、锌和铁含量增加相关的小麦数量性状基因座。原始野生小麦等位基因编码一种NAC转录因子(NAM-B1)，它可以加速衰老并增加从叶片到发育中的籽粒的营养物质再动员，而现代小麦品种携带的是一种非功能性的NAM-B1等位基因。通过RNA干扰降低多个NAM同源物的RNA水平可以延缓小麦衰老3周以上，并使小麦籽粒蛋白质、锌和铁的含量降低30%以上。
Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.