Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.
Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.
复制标题
通过灌注计算机断层扫描和 15O 标记的水正电子发射断层扫描测量肿瘤血流：一项比较研究。
DOI：
10.1097/rct.0b013e318182d2e0
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发表时间：
2009
影响因子：
1.3
通讯作者：
Charnsangavej,Chusilp
中科院分区：
文献类型：
--
作者：
Ng,ChaanS;Kodama,Yoshihisa;Mullani,NizarA;Barron,BruceJ;Wei,Wei;Herbst,RoyS;Abbruzzese,JamesL;Charnsangavej,Chusilp
Objectives:To compare blood flow measurements of tumors assessed by perfusion computed tomography (pCT) and the clinical gold standard of 15 O-labeled water positron emission tomography (15 O-PET).Methods:Blood flows were estimated by pCT (4-row multidetector, CT Perfusion 3.1) and 15 O-PET (Posicam, first-pass model) in 14 patients with solid tumors, totaling 22 index tumors and 57 matched pairs of examinations. Blood flow estimates were compared using t test, Bland-Altman, and linear mixed regression analyses.Results:There was no significant difference between the mean (SD) blood flow values measured by pCT and 15 O-PET: 25.9±15.4 and 27.8±14.0 mL/min per 100 g, respectively.Conclusions:The demonstration of a good correlation between pCT and 15 O-PET potentially enables the use of pCT, which is more widely available than 15 O-PET, when tumor blood flow estimates are required, particularly in the context of clinical studies.
