Cytomorphologic Features Found in Cerebrospinal Fluid Specimens of Hemophagocytic Lymphohistiocytosis Patients.
Cytomorphologic Features Found in Cerebrospinal Fluid Specimens of Hemophagocytic Lymphohistiocytosis Patients.
复制标题
噬血细胞性淋巴组织细胞增多症患者脑脊液标本中发现的细胞形态学特征。
DOI：
10.1093/ajcp/aqaa248
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发表时间：
2021
影响因子：
3.5
通讯作者：
Ho,Cheng-Ying
中科院分区：
文献类型：
--
作者：
Shyu,Susan;Luca,Dragos;VandenBussche,ChristopherJ;Ho,Cheng-Ying
70%的噬血细胞性淋巴组织细胞增生症（CNS-HLH）患者存在中枢神经系统受累。CNS-HLH定义为神经功能缺损、神经影像学异常或脑脊液（CSF）阳性。CSF细胞形态学谱的CNS-HLH，但是，还没有得到很好的investigated.MethodsA回顾性分析64例CSF标本从儿童和成人患者HLH。10例有临床放射学证据的中枢神经系统involvement.ResultsWe确定了五个CSF细胞形态学模式：（1）噬血细胞，（2）空泡化的巨噬细胞没有证据的噬血细胞，（3）单核细胞和/或nonvacuolated巨噬细胞，（4）无细胞标本，和（5）血液标本。1型和2型在CNS-HLH中常见，在无CNS受累的患者中罕见。CSF的细胞形态学模式没有相关性以及与WBC计数或蛋白concentration.ConclusionsOur研究提供了一个全面的视图从HLH患者的CSF标本中看到的细胞形态学特征。
ObjectivesCentral nervous system involvement is present in 70% of patients with hemophagocytic lymphohistiocytosis (CNS-HLH). CNS-HLH is defined by neurologic deficits, neuroimaging abnormalities, or positive cerebrospinal fluid (CSF) findings. The CSF cytomorphologic spectrum of CNS-HLH, however, has not been well investigated.MethodsA retrospective review was performed on 64 CSF specimens from pediatric and adult patients with HLH. Ten patients had clinicoradiologic evidence of CNS involvement.ResultsWe identified five CSF cytomorphologic patterns: (1) hemophagocytosis, (2) vacuolated macrophages without evidence of hemophagocytosis, (3) monocytes and/or nonvacuolated macrophages, (4) acellular specimens, and (5) bloody specimens. Patterns 1 and 2 were common in CNS-HLH and rare in patients without CNS involvement. The CSF cytomorphologic patterns did not correlate well with WBC counts or protein concentration.ConclusionsOur study offers a comprehensive view of the cytomorphologic features seen in CSF specimens from patients with HLH.