Noradrenergic alpha-2A receptor activation suppresses courtship vocalization in male Japanese quail.
Noradrenergic alpha-2A receptor activation suppresses courtship vocalization in male Japanese quail.
复制标题
去甲肾上腺素能 α-2A 受体激活抑制雄性日本鹌鹑的求偶发声。
DOI：
10.1016/j.bbr.2021.113513
复制
发表时间：
2021
影响因子：
2.7
通讯作者：
Tobari Y
中科院分区：
文献类型：
--
作者：
Tobari Y
雄性日本鹌鹑在繁殖季节会发出高频率的乌鸦叫声来吸引雌性。丘间核（ICo）是鸟类的中脑发声中心，电刺激ICo会产生包括啼叫在内的叫声。去甲肾上腺素在鹌鹑的性行为中起着重要的作用，但去甲肾上腺素在控制鹌鹑求偶叫声中的作用还没有得到很好的证实。侧脑室注射α2-肾上腺素能受体特异性激动剂可乐定，立即抑制乌鸦叫声。在同一时间，乌鸦抑制可乐定有立即早期基因，zenk mRNA的减少，在ICo，没有zenk mRNA的表达，在核的背内侧部检测。用组织化学方法，我们确定了ICo接受去甲肾上腺素能神经支配并表达α 2A肾上腺素能受体mRNA。这些结果提示去甲肾上腺素可能通过表达于ICO神经元的α 2A肾上腺素受体调节鹌鹑求偶期的鸣叫。
Male Japanese quail produce high-frequency crow vocalizations to attract females during the breeding season. The nucleus of intercollicularis (ICo) is the midbrain vocal center in birds and electrical stimulation of the ICo produces calls that include crowing. Noradrenaline plays a significant role in sexual behavior but the contribution of noradrenaline in the control of courtship vocalizations in quail has not been well established. Using dose-dependent intracerebroventricular injection of clonidine, an α2-adrenergic receptor-specific agonist, crowing vocalization was immediately suppressed. At the same time as crow suppression by clonidine there was a reduction of immediate early gene, zenk mRNA, in the ICo; no zenk mRNA expression was detected in the dorsomedial division of the nucleus. Using histochemistry, we determined that the ICo receives noradrenergic innervation and expresses α2A-adrenergic receptor mRNA. Taken together, these data suggest that noradrenaline regulates courtship vocalization in quail, possiblyviathe α2A-adrenergic receptor expressed on ICo neurons.