Prevalence of chronic kidney disease and its association with metabolic diseases: a cross-sectional survey in Zhejiang province, Eastern China.
Prevalence of chronic kidney disease and its association with metabolic diseases: a cross-sectional survey in Zhejiang province, Eastern China.
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慢性肾脏疾病的患病率及其与代谢疾病的关联：中国东部省省的横断面调查。
DOI：
10.1186/1471-2369-15-36
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发表时间：
2014-02-21
期刊：
影响因子：
2.3
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Lin B;Shao L;Luo Q;Ou-yang L;Zhou F;Du B;He Q;Wu J;Xu N;Chen J
我国不同地区慢性肾脏病（CKD）和代谢性疾病的患病率呈不同程度的上升趋势。本研究的目的是评估中国东部浙江省CKD的患病率，并分析CKD的相关危险因素。2009年9月至2012年6月，在中国东部的浙江省对11,013名成年人进行了横断面调查。CKD定义为估计肾小球滤过率（eGFR）< 60 mL/min/1.73 m2或存在蛋白尿。病史、体格检查和实验室数据用于诊断代谢性疾病。使用2010年中国人口分布数据计算年龄和性别标准化患病率。我们用多变量逻辑回归分析了与肾功能下降和蛋白尿相关的危险因素。共有10，384名成年人（94.3%）完成了筛查。肾功能下降（eGFR < 60 mL/min/1.73 m2）的标准化患病率为1.83%（95% CI 1.52-2.13），白蛋白尿的标准化患病率为8.65%（95% CI 7.98-9.31）。CKD的总患病率为9.88%（95%CI 9.18-10.59）。浙江省东部农村地区肾功能减退患病率较高。多因素Logistic回归分析显示糖尿病、肥胖、高血压、高尿酸血症等代谢性疾病是CKD的独立危险因素。有代谢性疾病者CKD患病率显著高于无代谢性疾病者（P < 0.001）。CKD已成为浙江省严重的公共卫生问题，代谢性疾病可能增加浙江省人群CKD的风险。
The prevalence of chronic kidney disease (CKD) and metabolic diseases has increased at different rates in different regions in China. The aim of our study was to estimate the prevalence of CKD and to analyze associated risk factors of CKD in Zhejiang province, Eastern China. A cross-sectional survey of 11,013 adults was conducted from September 2009 to June 2012 in Zhejiang Province, located in Eastern China. CKD was defined as having an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or the presence of albuminuria. Medical history, physical examination and laboratory data were used to diagnose metabolic diseases. Age- and sex-standardized prevalence was calculated using the data on the population distribution in China in 2010. We examined risk factors associated with decreased renal function and albuminuria using multivariate logistic regression. A total of 10,384 adults (94.3%) completed the screening. The standardized prevalence of reduced renal function (eGFR < 60 mL/min/1.73 m2) was 1.83% (95% CI 1.52–2.13) and that of albuminuria was 8.65% (95% CI 7.98–9.31). The overall prevalence of CKD was 9.88% (95% CI 9.18–10.59). The prevalence of reduced renal function was greater in the eastern rural areas in Zhejiang province. Multivariate logistic regression revealed that metabolic diseases such as diabetes, obesity, hypertension, and hyperuricemia were independent risk factors of CKD. Patients with metabolic diseases had a significantly (P < 0.001) higher prevalence of CKD than those without such diseases. CKD has become a severe public health problem in Zhejiang Province, and metabolic diseases may increase the risk of CKD in Zhejiang population.