3-Dimensional Bioprinting of Cardiovascular Tissues: Emerging Technology.
3-Dimensional Bioprinting of Cardiovascular Tissues: Emerging Technology.
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DOI：
10.1016/j.jacbts.2020.12.006
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Nguyen KL
中科院分区：
文献类型：
--
作者：
Sung K;Patel NR;Ashammakhi N;Nguyen KL
3D生物打印的进展在多种心血管应用的治疗开发方面具有巨大的潜力。3-三维生物打印正朝着体内研究发展，以评估打印的结构的功能性和安全性。生物打印技术主要使用基于挤出、喷墨和基于光的打印。生物墨水由细胞和基质材料组成，并且由基于支架和无支架的墨水组成。三维（3D）生物打印可以克服组织工程中的挑战。与传统的组织工程方法不同，3D生物打印具有支持更大规模结构血管化的能力，并已用于多种心血管应用。概述了3D生物打印技术，体内翻译和挑战。
Advances in 3D bioprinting have tremendous potential in therapeutic development for multiple cardiovascular applications. 3-dimensional bioprinting is moving toward in vivo studies to evaluate printed construct functionality and safety. Bioprinting techniques predominantly use extrusion-based, inkjet, and light-based printing. Bioinks are composed of cells and matrix material and consist of both scaffold-based and scaffold-free inks. Three-dimensional (3D) bioprinting may overcome challenges in tissue engineering. Unlike conventional tissue engineering approaches, 3D bioprinting has a proven ability to support vascularization of larger scale constructs and has been used for several cardiovascular applications. An overview of 3D bioprinting techniques, in vivo translation, and challenges are described.