Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6
Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6
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DOI：
10.1080/15592324.2017.1321188
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发表时间：
2017-05
影响因子：
2.9
通讯作者：
Kun Li;Fengbo Yang;Y. Miao;Chunpeng Song
中科院分区：
文献类型：
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作者：
Kun Li;Fengbo Yang;Y. Miao;Chunpeng Song
脱落酸（ABA）在植物生长发育和逆境响应中发挥重要作用。最近，我们发现ABA调节ABA不敏感蛋白激酶1 (ABA-insensitive protein kinase 1, AIK1)，这是一种丝裂原激活的蛋白激酶激酶。与野生型相比，aik1-1表达aba应答基因（RD29A、MYC2、ABI3和ABI4）下调。在ABA处理下，aik1-1中KRP1 （kip相关蛋白，一种周期蛋白依赖性激酶抑制剂）的转录水平低于野生型。aba激活的MPK6在abi1 abi2和abi1 abi2 hab1突变体中活性降低，在snrk2.2 snrk2.3和pyr1 pyl1 pyl2 pyl4突变体中活性升高。这些结果表明，AIK1-MKK5-MPK6在ABA应答中起作用，并且需要ABA应答基因表达来调节ABA抑制的根生长和细胞分裂。ABA信号通路调控MAPK级联反应。
ABSTRACT Abscisic acid (ABA) plays roles in plant growth and development and in stress responses. Recently, we found that ABA regulates ABA-insensitive protein kinase 1 (AIK1), a mitogen-activated protein kinase kinase kinase. Compared with wild-type, aik1–1 showed downregulation of ABA-responsive genes (RD29A, MYC2, ABI3 and ABI4). Under ABA treatment, the transcript level of KRP1 (Kip-related protein, a cyclin-dependent kinase inhibitor) was lower in aik1–1 than in wild-type. The activity of ABA-activated MPK6 was decreased in abi1 abi2, and abi1 abi2 hab1, and increased in snrk2.2 snrk2.3 and pyr1 pyl1 pyl2 pyl4 mutants. These results indicated that AIK1-MKK5-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK cascade.