Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer
Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer
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DOI：
10.1021/bm0494491
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发表时间：
2005-03-01
影响因子：
6.2
通讯作者：
Ouchi, T
中科院分区：
文献类型：
--
作者：
Arimura, H;Ohya, Y;Ouchi, T
合成了具有不同长度的亲水性和疏水性链段的聚（天冬氨酸）-嵌段-聚丙交酯二嵌段共聚物（PA.sp-b-PLAs）。这些 PAsp-b-PLA 二嵌段共聚物在水溶液中形成由疏水性 PLA 核和亲水性、pH 敏感的 PAsp 壳组成的聚合物胶束。研究了 PLA 和 PAsp 部分的链段长度以及溶液 pH 值对 PAsp-b-PLA 聚合物胶束形状和尺寸的影响。结果表明，静电斥力、PAsp 壳层中的氢键作用和 PLA 核中的疏水相互作用之间的平衡决定了 PAsp-b-PLA 聚合物胶束的尺寸。此外，PAsp-b-PLA 聚合物胶束对 L929 成纤维细胞不具有任何细胞毒活性。所获得的聚合物胶束应可用于可生物降解的生物医学材料，例如药物输送载体。
Poly(aspartic acid)-block-polylactide diblock copolymers (PA.sp-b-PLAs) having both hydrophilic and hydrophobic segments of various lengths were synthesized. These PAsp-b-PLA diblock copolymers formed polymeric micelles consisting of a hydrophobic PLA core and a hydrophilic, pH-sensitive PAsp shell in aqueous solution. The effects of the segment length of both the PLA and the PAsp portions and the pH of the solution on the shapes and sizes of the PAsp-b-PLA polymeric micelles were investigated. The results indicated a balance between the effects of electrostatic repulsion, hydrogen bonding in the PAsp shell layer, and hydrophobic interactions in the PLA core determine the sizes of the PAsp-b-PLA polymeric micelles. Moreover, the PAsp-b-PLA polymeric micelles did not possess any cytotoxic activity against L929 fibroblast cells. The obtained polymeric micelle should be useful for biodegradable biomedical materials such as drug delivery vehicle.