Acute Ultrastructural Changes in the Middle Cerebral Artery Due to the Injury and Ischemia of Surgical Clamping
Acute Ultrastructural Changes in the Middle Cerebral Artery Due to the Injury and Ischemia of Surgical Clamping
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DOI：
10.1017/s0317167100025956
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发表时间：
1976-02
期刊：
影响因子：
--
通讯作者：
R. Dodson;Y. Tagashira;L. Chu
中科院分区：
文献类型：
--
作者：
R. Dodson;Y. Tagashira;L. Chu
摘要：本文描述了应用手术夹后松鼠猴大脑中动脉夹紧区超微结构的变化。所采用的实验模型已广泛应用于脑缺血的研究，可能与脑血管疾病患者神经外科治疗中应用脑血管钳有关。动脉壁内最早的改变出现在平滑肌（中）和伴随的神经束。在血管夹断4小时后，神经束内的变化足够先进，表明血管夹断远端脑血管的神经源性神经支配暂时或永久受损。
SUMMARY: Ultrastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip. The experimental model utilized has been widely applied to the study of cerebral ischemia and possibly has relevance to clamps applied to the cerebral vessels during neurosurgical treatment of patients with cerebrovascular disorders. The earliest changes within the arterial wall were found in the smooth muscle (media) and accompanying fasciculi of nerves. Changes within the nerve bundles were sufficiently advanced following 4 hours of vascular clipping to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.