Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats
Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats
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DOI：
10.1016/s0306-4522(98)00693-9
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发表时间：
1999-04-01
期刊：
影响因子：
3.3
通讯作者：
Daszuta, A
中科院分区：
文献类型：
--
作者：
Brezun, JM;Daszuta, A
在成年期，神经元前体细胞存在于两个离散的区域，脑室下区（19）和海马颗粒下区（11），最近在灵长类动物中证实。(10)迄今为止，已知一些因子如肾上腺类固醇（9）和营养因子（13）调节成人神经发生。由于神经元活动也可能影响大脑中的细胞发育和可塑性，我们研究了5-羟色胺耗竭对这些区域细胞增殖的影响。事实上，除了作为神经递质的作用外，5-羟色胺（5-羟色胺）被认为是发育调节信号。(14 5-羟色胺的产前消耗延迟了5-羟色胺靶区域中神经发生的开始（14），并且5-羟色胺促进了皮质和海马神经元的分化。(15 23）虽然在成人大脑中，一些研究表明5-羟色胺可能通过维持皮质和海马中的突触连接而在神经元可塑性中发挥作用（3，6，16），但实际上没有关于5-羟色胺对成人神经发生影响的信息。如果进一步的工作证实，新的神经元可以产生在成年人的大脑中是各种物种的情况下，它是特别相关的，以确定5-羟色胺对海马结构的神经发生的影响，除了大脑主要涉及学习和记忆过程。事实上，海马体中缺乏5-羟色胺与认知障碍有关，如抑郁症，精神分裂症（1）和阿尔茨海默病。(7)在本研究中，我证明，抑制5-羟色胺的合成和选择性病变的5-羟色胺神经元与齿状回，以及在脑室下区的新产生的细胞的数量减少。(C)1999年IBRO。出版社：Elsevier Science Ltd
During adulthood, neuronal precursor cells persist in two discrete regions, the subventricular zone(19) and the hippocampal subgranular zone,(11) as recently demonstrated in primates.(10) To date, a few factors such as adrenal steroids(9) and trophic factors(13) are known to regulate adult neurogenesis. Since neuronal activity may also influence cellular development and plasticity in brain, we investigated the effects of serotonin depletion on cell proliferation occurring in these regions. Indeed, in addition to its role as a neurotransmitter, 5-hydroxytryptamine (serotonin) is considered as a developmental regulatory signal.(14,22) Prenatal depletion in 5-hydroxytryptamine delays the onset of neurogenesis in 5-hydroxytryptamine target regions(14) and 5-hydroxytryptamine promotes the differentiation of cortical and hippocampal neurons.(15,23) Although in the adult brain, a few studies have suggested that 5-hydroxytryptamine may play a role in neuronal plasticity by maintaining the synaptic connections in the cortex and hippocampus,(3,6,16) no information is actually available concerning the influence of 5-hydroxytryptamine on adult neurogenesis. If further work confirms that new neurons can be produced in the adult human brain as is the case for a variety of species, it is particularly relevant to determine the influence of 5-hydroxytryptamine on neurogenesis in the hippocampal formation, apart of the brain largely implicated in learning and memory processes. Indeed, lack of 5-hydroxytryptamine in the hippocampus has been associated with cognitive disorders, such as depression, schizophrenia(1) and Alzheimer's disease.(7) In the present study, me demonstrated that both inhibition of 5-hydroxytryptamine synthesis and selective lesions of 5-hydroxytryptamine neurons are associated with decreases in the number of newly generated cells in the dentate gyrus, as well as in the subventricular zone. (C) 1999 IBRO. Published by Elsevier Science Ltd.