Phosphorus and Nitrogen Dual-Doped Hollow Carbon Dot as a Nanocarrier for Doxorubicin Delivery and Biological Imaging
Phosphorus and Nitrogen Dual-Doped Hollow Carbon Dot as a Nanocarrier for Doxorubicin Delivery and Biological Imaging
复制标题
磷氮双掺杂空心碳点作为纳米载体用于阿霉素输送和生物成像
DOI：
10.1021/acsami.6b01577
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发表时间：
2016-05-11
影响因子：
9.5
通讯作者：
Dong, Chuan
中科院分区：
文献类型：
--
作者：
Gong, Xiaojuan;Zhang, Qingyan;Dong, Chuan
创新的磷、氮双掺杂中空碳点(PNHCD)已被制备用于抗癌药物输送和生物成像。PNHCD的官能团是通过简单地混合葡萄糖、1，2-乙二胺和浓磷酸来引入的。这是一种无需外部热处理的自动化方法，可以快速大量生产PNHCD，避免了高温、复杂的操作和较长的反应时间。所制备的PNHCDS具有小的颗粒尺寸、中空的结构和丰富的磷酸/羟基/吡啶/吡咯类N基团，赋予了PNHCDS荧光性质，提高了PNHCDS作为体内外光学监测代码的准确性。PNHCDS作为阿霉素(DOX)的抗癌药物纳米载体的研究表明，与游离DOX相比，PNHCDS具有更好的抗肿瘤效果，这是因为它在体外增强了核递送，在体内积累了肿瘤，从而高效地抑制了肿瘤的生长，提高了临床上对肿瘤的靶向治疗。
Innovative phosphorus and nitrogen dual-doped hollow carbon dots (PNHCDs) have been fabricated for anticancer drug delivery and biological imaging. The functional groups of PNHCDs are introduced by simply mixing glucose, 1,2-ethylenediamine, and concentrated phosphoric acid. This is an automatic method without external heat treatment to rapidly produce large quantities of PNHCDs, which avoid high temperature, complicated operations, and long reaction times. The as-prepared PNHCDs possess small particle size, hollow structure, and abundant phosphate/hydroxyl/pyridinic/pyrrolic-like N groups, endowing PNHCDs with fluorescent properties, improving the accuracy of PNHCDs as an optical monitoring code both in vitro and in vivo. The investigation of PNHCDs as an anticancer drug nanocarrier for doxorubicin (DOX) indicates a better antitumor efficacy than free DOX owing to its enhanced nuclear delivery in vitro and tumor accumulation in vivo, which results in highly effective tumor growth inhibition and improved targeted therapy for cancer in clinical medicine.