Quantitative assessment of pressure sore generation and healing through numerical analysis of high-frequency ultrasound images
Quantitative assessment of pressure sore generation and healing through numerical analysis of high-frequency ultrasound images
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DOI：
10.1682/jrrd.2009.04.0045
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发表时间：
2010-01-01
影响因子：
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通讯作者：
Mahloojifar, Ali
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文献类型：
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作者：
Moghimi, Sahar;Baygi, Mohammad Hossein Miran;Mahloojifar, Ali
本文重点介绍一种使用高频 (20 MHz) 超声图像定量评估人工诱发压疮愈合过程的方法。我们在豚鼠中诱发溃疡，并在溃疡产生后第 3、7、14 和 21 天监测预先定义的区域。我们提取了有关组织回波结构和衰减特性的相关参数。我们通过定义使用提取的参数的愈合函数来检查组织愈合。我们通过方差分析和多重比较测试验证了提取特征的显着性。这些特征在伤口生成过程中表现出上升/下降行为，在愈合过程中表现出反向行为。我们通过使用模式搜索方法优化了治疗功能的参数。我们通过计算评估日的愈合功能值，然后将这些结果与去除施加的压力后组织状况的预期变化模式进行比较，来测试优化值的效率。这项研究的结果表明，所开发的方法可能是定量评估压疮早期和愈合阶段的可行工具。
This article focuses on the development of a method to quantitatively assess the healing process of artificially induced pressure sores using high-frequency (20 MHz) ultrasound images. We induced sores in guinea pigs and monitored pre-defined regions on days 3, 7, 14, and 21 after sore generation. We extracted relevant parameters regarding the tissue echographic structure and attenuation properties. We examined tissue healing by defining a healing function that used the extracted parameters. We verified the significance of the extracted features by using analysis of variance and multiple comparison tests. The features displayed ascending/descending behavior during wound generation and reverse behavior during healing. We optimized the parameters of our healing function by using a pattern search method. We tested the efficiency of the optimized values by calculating the healing function value on assessment days and then comparing these results with the expected pattern of changes in the tissue conditions after removing the applied pressure. The results of this study suggest that the methodology developed may be a viable tool for quantitative assessment of pressure sores during their early generation as well as during healing stages.