Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.
Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.
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DOI：
10.1016/j.tcsw.2021.100063
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Miller GJ
中科院分区：
文献类型：
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作者：
Ahmadipour S;Field RA;Miller GJ
真菌感染对人类的影响是一个严重的公共卫生问题，与细菌感染和治疗相比，它受到的关注要少得多，尽管发病率不断上升，但人口中免疫功能低下的人的发病率增加加剧了这一问题。尤其是念珠菌，会引起一些最普遍的与医院相关的真菌感染。真菌感染也对放牧牲畜的健康有害，奶牛的产奶量以及身体和皮毛状况受到真菌感染的不利影响。真菌细胞壁对于真菌的存活、形态发生和发病机制是必不可少的：许多抗真菌药物依赖于靶向细胞壁或细胞膜，但可用生物活性物质的管道是有限的。有一个明确的和尚未得到满足的需求，即确定新的目标和开发新的抗真菌药物类别。本文对包括金黄色念珠菌在内的假丝酵母菌的细胞壁结构、组成和生物合成进行了综述。此外，还对细胞壁靶向治疗发展的最新进展进行了综述。
The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised individuals in the population. Candida species, in particular, cause some of the most prevalent hospital-related fungal infections. Fungal infections are also detrimental to the well-being of grazing livestock, with milk production in dairy cows, and body and coat condition adversely affected by fungal infections. Fungal cell walls are essential for viability, morphogenesis and pathogenesis: numerous anti-fungal drugs rely on targeting either the cell wall or cell membrane, but the pipeline of available bioactives is limited. There is a clear and unmet need to identify novel targets and develop new classes of anti-fungal agents. This mini review focuses on fungal cell wall structure, composition and biosynthesis in Candida spp., including C. auris. In addition, an overview of current advances in the development of cell wall targeted therapies is considered.